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Tbio
CRB1
Protein crumbs homolog 1

Protein Summary
Description
Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367399
  • ENSP00000356369
  • ENSG00000134376
  • ENST00000367400
  • ENSP00000356370
  • ENST00000484075
  • ENSP00000433932
  • ENST00000538660
  • ENSP00000438091
  • ENST00000638467
  • ENSP00000491102

Symbol
  • LCA8
  • RP12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.83
kinase perturbation
0.66
phenotype
0.64
tissue sample
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.67   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.67   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
2
1
6.3
91.5
heel bone mineral density
2
1
2
83.2
Oral ulcer
1
1
0
1
80
depressive symptom measurement
1
1
1
79.2
1
1
0
1.4
76.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
6.3
91.5
heel bone mineral density
2
83.2
Oral ulcer
0
1
80
depressive symptom measurement
1
79.2
0
1.4
76.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crumbs 1, cell polarity complex component
VGNC:1224
469626
Macaque
crumbs 1, cell polarity complex component
710991
Mouse
MGI:2136343
170788
Rat
RGD:1309947
304825
Dog
crumbs 1, cell polarity complex component
VGNC:39593
490260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crumbs 1, cell polarity complex component
Macaque
crumbs 1, cell polarity complex component
Mouse
Rat
Dog
crumbs 1, cell polarity complex component
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P82279-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (134)
1 – 10 of 134
MPP5
Tbio
Novelty: 0.01707773
Score: 0.993
Data Source: STRINGDB
PATJ
Tbio
Novelty: 0.01420008
Score: 0.921
Data Source: STRINGDB
AIPL1
Tbio
Novelty: 0.01436649
Score: 0.855
Data Source: STRINGDB
RDH12
Tbio
Family: Enzyme
Novelty: 0.016003
Score: 0.824
Data Source: STRINGDB
CRB2
Tbio
Novelty: 0.02380675
Score: 0.822
Data Source: STRINGDB
TULP1
Tbio
Family: TF
Novelty: 0.0192093
Score: 0.821
Data Source: STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.803
Data Source: STRINGDB
GUCY2D
Tbio
Family: Kinase
Novelty: 0.00578343
Score: 0.798
Data Source: STRINGDB
RPE65
Tbio
Family: Enzyme
Novelty: 0.00147985
Score: 0.796
Data Source: STRINGDB
CRB3
Tbio
Novelty: 0.05397064
Score: 0.76
Data Source: STRINGDB
Publication Statistics
PubMed Score  182.67

PubMed score by year
PubTator Score  114.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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