Tbio SLC7A9 b(0,+)-type amino acid transporter 1

Protein Summary

Description

Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule. This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011]

Uniprot Accession IDs

• P82251
• B2R9A6
• b(0,+)AT1

Gene Name

• SLC7A9

Ensembl ID

• ENST00000023064
• ENSP00000023064
• ENSG00000021488
• ENST00000587772
• ENSP00000468439
• ENST00000590341
• ENSP00000464822

Symbol

• BAT1
• BAT1
• CSNU3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
gene perturbation	0.63
tissue sample	0.63
PubMedID	0.57
cell line	0.56

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc3 And Slc7 Families Of Heteromeric Amino Acid Transporters (Hats) / Slc7 Family / B(0,+)-type Amino Acid Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.02   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 80   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.02   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0