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Tbio
SLC7A9
b(0,+)-type amino acid transporter 1

Protein Summary
Description
Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule. This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000023064
  • ENSP00000023064
  • ENSG00000021488
  • ENST00000587772
  • ENSP00000468439
  • ENST00000590341
  • ENSP00000464822

Symbol
  • BAT1
  • BAT1
  • CSNU3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
gene perturbation
0.63
tissue sample
0.63
PubMedID
0.57
cell line
0.56


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.78   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.78   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
7
9
10.9
98.5
urinary metabolite measurement
5
4
15
94.1
creatinine measurement
6
7
9
91.8
hemoglobin measurement
2
2
2
87.2
urate measurement
4
4
4
86.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
10.9
98.5
urinary metabolite measurement
15
94.1
creatinine measurement
9
91.8
hemoglobin measurement
2
87.2
urate measurement
4
86.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 9
VGNC:12108
742762
Macaque
solute carrier family 7 member 9
703081
Mouse
MGI:1353656
30962
Rat
RGD:619905
116726
Dog
solute carrier family 7 member 9
VGNC:46479
484601
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 9
Macaque
solute carrier family 7 member 9
Mouse
Rat
Dog
solute carrier family 7 member 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P82251-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Defective SLC3A1 causes cystinuria (CSNU)
Reactome
Defective SLC7A9 causes cystinuria (CSNU)
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Basigin interactions
Cell surface interactions at the vascular wall
Defective SLC3A1 causes cystinuria (CSNU)
Defective SLC7A9 causes cystinuria (CSNU)
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (66)
1 – 10 of 66
SLC3A1
Tbio
Family:  Transporter
Novelty:  0.003328
Score:  0.994
Data Source:  Reactome,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.98
Data Source:  STRINGDB
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
Score:  0.959
Data Source:  Reactome,STRINGDB
BSG
Tbio
Novelty:  0.0010285
Score:  0.9
Data Source:  STRINGDB
RPS15A
Tbio
Novelty:  0.03502821
Score:  0.759
Data Source:  STRINGDB
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
Score:  0.744
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.726
Data Source:  STRINGDB
SLC6A19
Tchem
Family:  Transporter
Novelty:  0.01581031
Score:  0.706
Data Source:  STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
Score:  0.668
Data Source:  STRINGDB
SLC6A20
Tbio
Family:  Transporter
Novelty:  0.01435823
Score:  0.665
Data Source:  STRINGDB
Publication Statistics
PubMed Score  105.78

PubMed score by year
PubTator Score  128.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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