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Tbio
DCD
Dermcidin

Protein Summary
Description
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443). Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia ( ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293371
  • ENSP00000293371
  • ENSG00000161634
  • ENST00000456047
  • ENSP00000406773
  • ENST00000546807
  • ENSP00000450415

Symbol
  • AIDD
  • DSEP
  • PIF
  • AIDD
  • DSEP
  • HCAP
  • DCD-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.98
tissue
0.62
hub protein
0.53
cell line
0.49


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.82   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.82   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dermcidin
VGNC:5352
748033
Macaque
dermcidin [Source:HGNC Symbol;Acc:HGNC:14669]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dermcidin
Macaque
dermcidin [Source:HGNC Symbol;Acc:HGNC:14669]
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P81605-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (14)
1 – 10 of 14
PITX2
Tbio
Family:  TF
Novelty:  0.00216568
Score:  0.741
Data Source:  STRINGDB
RNASE7
Tbio
Family:  Enzyme
Novelty:  0.01866347
Score:  0.67
Data Source:  STRINGDB
CAMP
Tbio
Novelty:  0.00064433
Score:  0.669
Data Source:  STRINGDB
DEFB103A
Tbio
Novelty:  0.00328986
Score:  0.641
Data Source:  STRINGDB
S100A7
Tbio
Novelty:  0.00434262
Score:  0.63
Data Source:  STRINGDB
LACRT
Tbio
Novelty:  0.03333799
Score:  0.487
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.453
Data Source:  STRINGDB
FBXO32
Tbio
Novelty:  0.00225437
Score:  0.443
Data Source:  STRINGDB
LCE1C
Tdark
Novelty:  0.81589958
Score:  0.443
Data Source:  STRINGDB
AZGP1
Tbio
Novelty:  0.00448545
Score:  0.43
Data Source:  STRINGDB
Publication Statistics
PubMed Score  235.82

PubMed score by year
PubTator Score  268.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer