Tbio DCD Dermcidin

Protein Summary

Description

DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443). Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P81605
• A5JHP2
• A5JHP3
• P58461
• Q53YJ2

Gene Name

• DCD

Ensembl ID

• ENST00000293371
• ENSP00000293371
• ENSG00000161634
• ENST00000456047
• ENSP00000406773
• ENST00000546807
• ENSP00000450415

Symbol

• AIDD
• DSEP
• PIF
• AIDD
• DSEP
• HCAP
• DCD-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
interacting protein	0.98
tissue	0.62
hub protein	0.53
cell line	0.49

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.82   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 235.82   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	dermcidin	VGNC:5352	748033
Macaque	dermcidin [Source:HGNC Symbol;Acc:HGNC:14669]

Species	Name	OMA	EggNOG	Inparanoid
Chimp	dermcidin
Macaque	dermcidin [Source:HGNC Symbol;Acc:HGNC:14669]

Protein Structure (3 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P81605-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

Reactome (3)

Antimicrobial peptides (R-HSA-6803157)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Antimicrobial peptides	89 targets	R-HSA-6803157
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Gene Ontology Terms (12)

Functions (2)

Components (3)

Processes (7)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
peptidase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (14)

Explore Interacting Targets

1 – 10 of 14

• See Interactions on String-DB

PITX2

Tbio

Family:  TF

Novelty:  0.00216568

Score:  0.741

Data Source:  STRINGDB

RNASE7

Tbio

Family:  Enzyme

Novelty:  0.01866347

Score:  0.67

Data Source:  STRINGDB

CAMP

Tbio

Novelty:  0.00064433

Score:  0.669

Data Source:  STRINGDB

DEFB103A

Tbio

Novelty:  0.00328986

Score:  0.641

Data Source:  STRINGDB

S100A7

Tbio

Novelty:  0.00434262

Score:  0.63

Data Source:  STRINGDB

LACRT

Tbio

Novelty:  0.03333799

Score:  0.487

Data Source:  STRINGDB

DEFB1

Tbio

Novelty:  0.00144458

Score:  0.453

Data Source:  STRINGDB

FBXO32

Tbio

Novelty:  0.00225437

Score:  0.443

Data Source:  STRINGDB

LCE1C

Tdark

Novelty:  0.81589958

Score:  0.443

Data Source:  STRINGDB

AZGP1

Tbio

Novelty:  0.00448545

Score:  0.43

Data Source:  STRINGDB

Publication Statistics

PubMed Score  235.82

PubMed score by year

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PubTator Score  268.91

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Antibiotic
Antimicrobial
Complete proteome
Direct protein sequencing
Fungicide
Hydrolase
Manganese