You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DEFB103A
Beta-defensin 103

Protein Summary
Description
Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314357
  • ENSP00000320951
  • ENSG00000176797
  • ENST00000318124
  • ENSP00000324633
  • ENSG00000177243
  • ENST00000613448
  • ENSP00000480773
  • ENSG00000273641
  • ENST00000642635
  • ENSP00000495040
  • ENSG00000285376
  • ENST00000646258
  • ENSP00000493640
  • ENST00000646344
  • ENSP00000493616
  • ENSG00000284978

Symbol
  • BD3
  • DEFB103
  • DEFB3
  • BD-3
  • HBD3
  • HBP3
  • DEFB3
  • HBP-3
  • DEFB-3
  • DEFB103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.85
disease
0.57
cell line
0.54
tissue
0.47
phenotype
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 386.51   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 386.51   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0