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Tbio
FAM189B
Protein FAM189B

Protein Summary
Description
This gene is located near the gene for the lysosomal enzyme glucosylceramidase; a deficiency in this enzyme is associated with Gaucher disease. The encoded protein has been identified as a potential binding partner of a WW domain-containing protein which is involved in apoptosis and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350210
  • ENSP00000307128
  • ENSG00000160767
  • ENST00000361361
  • ENSP00000354958
  • ENST00000368368
  • ENSP00000357352
  • ENST00000572488
  • ENSP00000458501
  • ENSG00000262666
  • ENST00000574749
  • ENSP00000460960
  • ENST00000575430
  • ENSP00000461152

Symbol
  • C1orf2
  • COTE1
  • COTE1
  • C1orf2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.85
kinase perturbation
0.81
transcription factor binding site profile
0.65
histone modification site profile
0.59
tissue sample
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (86)
Items per page:
1 – 5 of 86
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
5
9
98.3
urate measurement
6
5
9
98.3
serum urea measurement
2
3
3
95.4
serum urea measurement
2
3
3
95.4
serum gamma-glutamyl transferase measurement
2
3
2
3.7
94.6
Items per page:
1 – 5 of 86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
98.3
urate measurement
9
98.3
serum urea measurement
3
95.4
serum urea measurement
3
95.4
serum gamma-glutamyl transferase measurement
2
3.7
94.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 189 member B
VGNC:10625
457362
Macaque
family with sequence similarity 189 member B
719116
Mouse
MGI:1915771
68521
Rat
RGD:1306107
310640
Dog
family with sequence similarity 189 member B
VGNC:40639
490428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 189 member B
Macaque
family with sequence similarity 189 member B
Mouse
Rat
Dog
family with sequence similarity 189 member B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P81408-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (89)
1 – 10 of 89
WWOX
Tbio
Family:  Enzyme
Novelty:  0.00335243
p_int:  0.999999989
p_ni:  1.1e-8
Score:  0.533
Data Source:  BioPlex,STRINGDB
HECW1
Tbio
Family:  Enzyme
Novelty:  0.15200354
p_int:  0.999999953
p_ni:  1.2e-8
p_wrong:  3.4e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
p_int:  0.999999896
p_ni:  9.4e-8
p_wrong:  1e-8
Score:  0.313
Data Source:  BioPlex,STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
p_int:  0.999997253
p_ni:  0.000002747
Score:  0.192
Data Source:  BioPlex,STRINGDB
CYHR1
Tdark
Novelty:  0.04771996
p_int:  0.999996392
p_ni:  0.000002859
p_wrong:  7.49e-7
Data Source:  BioPlex
NEDD4
Tchem
Family:  Enzyme
Novelty:  0.00281725
p_int:  0.99998787
p_ni:  0.00001213
Score:  0.22
Data Source:  BioPlex,STRINGDB
RNF111
Tbio
Family:  Enzyme
Novelty:  0.03059486
p_int:  0.999957805
p_ni:  0.000021491
p_wrong:  0.000020704
Data Source:  BioPlex
SMO
Tclin
Family:  GPCR
Novelty:  0.03235855
p_int:  0.99995352
p_ni:  0.000046396
p_wrong:  8.4e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
ABCD4
Tbio
Family:  Transporter
Novelty:  0.04096359
p_int:  0.999935215
p_ni:  0.00006478
p_wrong:  5e-9
Data Source:  BioPlex
ANKRD13D
Tdark
Novelty:  2.14380936
p_int:  0.999845877
p_ni:  0.000154123
Score:  0.539
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.19

PubMed score by year
PubTator Score  5.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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