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Tdark
PRLH
Prolactin-releasing peptide

Protein Summary
Description
Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000165524
  • ENSP00000165524
  • ENSG00000071677

Symbol
  • PRH
  • PRH
  • PRRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.67
cell line
0.49
biological process
0.46
phenotype
0.45
tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (52)
1 – 10 of 52
PRLHR
Tchem
Family:  GPCR
Novelty:  0.05024441
Score:  0.989
Data Source:  Reactome,STRINGDB
NPFF
Tbio
Novelty:  0.00489546
Score:  0.822
Data Source:  STRINGDB
QRFP
Tbio
Novelty:  0.02210773
Score:  0.813
Data Source:  STRINGDB
NPVF
Tdark
Novelty:  0.01627922
Score:  0.682
Data Source:  STRINGDB
NPFFR2
Tchem
Family:  GPCR
Novelty:  0.01703886
Score:  0.678
Data Source:  STRINGDB
PRL
Tbio
Novelty:  0.0000905
Score:  0.678
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.671
Data Source:  STRINGDB
GRIP2
Tdark
Novelty:  0.0661318
Score:  0.645
Data Source:  STRINGDB
SOS2
Tbio
Novelty:  0.01607832
Score:  0.621
Data Source:  STRINGDB
GRAP2
Tbio
Novelty:  0.00503901
Score:  0.62
Data Source:  STRINGDB
Pathways (12)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
4
78.2
5
4
0
1.1
64.8
central corneal thickness
1
1
0
1.6
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
78.2
0
1.1
64.8
central corneal thickness
0
1.6
17.8
Find similar targets by:
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3644668
623503
Rat
RGD:628634
63850
Dog
prolactin releasing hormone
VGNC:49715
111092307
Horse
prolactin releasing hormone [Source:HGNC Symbol;Acc:HGNC:17945]
Cow
prolactin releasing hormone
VGNC:33344
286856
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
prolactin releasing hormone
Horse
prolactin releasing hormone [Source:HGNC Symbol;Acc:HGNC:17945]
Cow
prolactin releasing hormone
Publication Statistics
PubMed Score 183.73
PubMed score by year
PubTator Score 69.39
PubTator score by year