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Tbio
HAMP
Hepcidin

Protein Summary
Description
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317). The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-tran ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222304
  • ENSP00000222304
  • ENSG00000105697
  • ENST00000598398
  • ENSP00000471894

Symbol
  • HEPC
  • LEAP1
  • HEPC
  • PLTR
  • HFE2B
  • LEAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
small molecule perturbation
0.6
cell type or tissue
0.58
disease
0.58
co-expressed gene
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3472.35   (req: < 5)
Gene RIFs: 383   (req: <= 3)
Antibodies: 404   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3472.35   (req: >= 5)
Gene RIFs: 383   (req: > 3)
Antibodies: 404   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
HJV
Tbio
Novelty:  0.00495995
Score:  0.969
Data Source:  STRINGDB
TFR2
Tbio
Family:  Enzyme
Novelty:  0.00480264
Score:  0.968
Data Source:  STRINGDB
HFE
Tbio
Novelty:  0.00042077
Score:  0.968
Data Source:  STRINGDB
SLC40A1
Tchem
Family:  Transporter
Novelty:  0.00222468
Score:  0.965
Data Source:  STRINGDB
TMPRSS6
Tchem
Family:  Enzyme
Novelty:  0.00739906
Score:  0.94
Data Source:  STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
Score:  0.921
Data Source:  STRINGDB
SLC11A2
Tchem
Family:  Transporter
Novelty:  0.00189409
Score:  0.914
Data Source:  STRINGDB
CREB3L3
Tbio
Family:  TF
Novelty:  0.02519904
Score:  0.904
Data Source:  STRINGDB
EPO
Tbio
Novelty:  0.00013701
Score:  0.902
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.892
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
5
7
92.3
reticulocyte count
7
3
7
92
reticulocyte measurement
3
2
3
83.3
mean corpuscular hemoglobin concentration
1
1
1
73.5
red blood cell density measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
92.3
reticulocyte count
7
92
reticulocyte measurement
3
83.3
mean corpuscular hemoglobin concentration
1
73.5
red blood cell density measurement
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hepcidin antimicrobial peptide
VGNC:2552
744861
Macaque
hepcidin antimicrobial peptide
708397
Mouse
MGI:2153530
66438
Rat
RGD:70971
84604
Dog
hepcidin antimicrobial peptide
VGNC:41588
492281
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hepcidin antimicrobial peptide
Macaque
hepcidin antimicrobial peptide
Mouse
Rat
Dog
hepcidin antimicrobial peptide
Publication Statistics
PubMed Score 3472.35
PubMed score by year
PubTator Score 1718.33
PubTator score by year
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Related Publications
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PMID
Year
Title