Protein Summary
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317). The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-tran ...more
- ENST00000222304
- ENSP00000222304
- ENSG00000105697
- ENST00000598398
- ENSP00000471894
- HEPC
- LEAP1
- HEPC
- PLTR
- HFE2B
- LEAP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
small molecule perturbation | 0.6 | ||
cell type or tissue | 0.58 | ||
disease | 0.58 | ||
co-expressed gene | 0.48 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2675.12 (req: < 5)
Gene RIFs: 383 (req: <= 3)
Antibodies: 404 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2675.12 (req: >= 5)
Gene RIFs: 383 (req: > 3)
Antibodies: 404 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 36
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (6)
KEGG (1)
WikiPathways (5)
Items per page:
1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | TGF-beta signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
TGF-beta signaling pathway | ||||
Gene Ontology Terms (41)
Functions (3)
Components (5)
Processes (33)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Protein-Protein Interactions (102)
1 – 10 of 102
HJV
Novelty: 0.00627463
Score: 0.969
Data Source: STRINGDB
TFR2
Family: Enzyme
Novelty: 0.00674542
Score: 0.968
Data Source: STRINGDB
HFE
Novelty: 0.00040976
Score: 0.968
Data Source: STRINGDB
SLC40A1
Family: Transporter
Novelty: 0.00310456
Score: 0.965
Data Source: STRINGDB
TMPRSS6
Family: Enzyme
Novelty: 0.00768229
Score: 0.94
Data Source: STRINGDB
LCN2
Family: Enzyme
Novelty: 0.00038637
Score: 0.921
Data Source: STRINGDB
SLC11A2
Family: Transporter
Novelty: 0.00250176
Score: 0.914
Data Source: STRINGDB
CREB3L3
Family: TF
Novelty: 0.02714115
Score: 0.904
Data Source: STRINGDB
EPO
Novelty: 0.00017234
Score: 0.902
Data Source: STRINGDB
IL6
Novelty: 0.00002829
Score: 0.892
Data Source: STRINGDB
Publication Statistics
PubMed Score 2675.12
PubMed score by year
PubTator Score 1718.33
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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