Protein Summary
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005). Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa (PubMed:11113131, PubMed:11034317). The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-tran ...more
- ENST00000222304
- ENSP00000222304
- ENSG00000105697
- ENST00000598398
- ENSP00000471894
- HEPC
- LEAP1
- HEPC
- PLTR
- HFE2B
- LEAP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
small molecule perturbation | 0.6 | ||
cell type or tissue | 0.58 | ||
disease | 0.58 | ||
co-expressed gene | 0.48 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3472.35 (req: < 5)
Gene RIFs: 383 (req: <= 3)
Antibodies: 404 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3472.35 (req: >= 5)
Gene RIFs: 383 (req: > 3)
Antibodies: 404 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 36
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (102)
Nearest Tclin Targets
Pathways (6)
KEGG (1)
WikiPathways (5)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | TGF-beta signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
TGF-beta signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (41)
Functions (3)
Components (5)
Processes (33)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 5 | 7 | 92.3 | |||||
reticulocyte count | 7 | 3 | 7 | 92 | |||||
reticulocyte measurement | 3 | 2 | 3 | 83.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 73.5 | |||||
red blood cell density measurement | 1 | 1 | 1 | 53.7 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 7 | 92.3 | |||||
reticulocyte count | 7 | 92 | |||||
reticulocyte measurement | 3 | 83.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 73.5 | |||||
red blood cell density measurement | 1 | 53.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hepcidin antimicrobial peptide | VGNC:2552 | 744861 | |||||
Macaque | hepcidin antimicrobial peptide | 708397 | ||||||
Mouse | MGI:2153530 | 66438 | ||||||
Rat | RGD:70971 | 84604 | ||||||
Dog | hepcidin antimicrobial peptide | VGNC:41588 | 492281 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hepcidin antimicrobial peptide | |||||
Macaque | hepcidin antimicrobial peptide | |||||
Mouse | ||||||
Rat | ||||||
Dog | hepcidin antimicrobial peptide | |||||
Publication Statistics
PubMed Score 3472.35
PubMed score by year
PubTator Score 1718.33
PubTator score by year
Related Publications
Text Mined References (395)
GeneRif Annotations (383)
Items per page:
0 of 0
PMID | Year | Title |
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