SIM1
Single-minded homolog 1
Protein Summary
Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
- ENST00000262901
- ENSP00000262901
- ENSG00000112246
- ENST00000369208
- ENSP00000358210
- BHLHE14
- bHLHe14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
gene perturbation | 0.8 | ||
PubMedID | 0.6 | ||
phenotype | 0.56 | ||
disease | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.68 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 153 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.68 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 153 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (4)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 1 | 1 | 58.4 | |||||
balding measurement | 1 | 2 | 2 | 56.8 | |||||
hematocrit | 1 | 1 | 1 | 56.2 | |||||
neuroticism measurement | 3 | 3 | 1 | 5.6 | 53.7 | ||||
glomerular filtration rate | 2 | 2 | 2 | 47.5 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 58.4 | |||||
balding measurement | 2 | 56.8 | |||||
hematocrit | 1 | 56.2 | |||||
neuroticism measurement | 1 | 5.6 | 53.7 | ||||
glomerular filtration rate | 2 | 47.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SIM bHLH transcription factor 1 | VGNC:7909 | 472084 | |||||
Macaque | single-minded family bHLH transcription factor 1 | 695324 | ||||||
Mouse | MGI:98306 | 20464 | ||||||
Rat | RGD:1309949 | 309888 | ||||||
Dog | SIM bHLH transcription factor 1 | VGNC:46174 | 481937 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SIM bHLH transcription factor 1 | |||||
Macaque | single-minded family bHLH transcription factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SIM bHLH transcription factor 1 | |||||
Publication Statistics
PubMed Score 208.68
PubMed score by year
PubTator Score 59.49
PubTator score by year
Related Publications
Text Mined References (39)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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