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Tbio
SIM1
Single-minded homolog 1

Protein Summary
Description
Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or cognitive disability of Down syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262901
  • ENSP00000262901
  • ENSG00000112246
  • ENST00000369208
  • ENSP00000358210

Symbol
  • BHLHE14
  • bHLHe14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.8
PubMedID
0.6
phenotype
0.56
disease
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.68   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.68   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
ARNT2
Tbio
Family:  TF
Novelty:  0.01485424
Score:  0.871
Data Source:  STRINGDB
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
Score:  0.868
Data Source:  STRINGDB
OTP
Tbio
Family:  TF
Novelty:  0.01535446
Score:  0.808
Data Source:  STRINGDB
MC4R
Tclin
Family:  GPCR
Novelty:  0.00091593
Score:  0.716
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.71
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.686
Data Source:  STRINGDB
POU3F2
Tbio
Family:  TF
Novelty:  0.00649458
Score:  0.671
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.663
Data Source:  STRINGDB
MCHR2
Tchem
Family:  GPCR
Novelty:  0.01191922
Score:  0.631
Data Source:  STRINGDB
TRH
Tbio
Novelty:  0.00052673
Score:  0.62
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
58.4
balding measurement
1
2
2
56.8
hematocrit
1
1
1
56.2
neuroticism measurement
3
3
1
5.6
53.7
glomerular filtration rate
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
58.4
balding measurement
2
56.8
hematocrit
1
56.2
neuroticism measurement
1
5.6
53.7
glomerular filtration rate
2
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIM bHLH transcription factor 1
VGNC:7909
472084
Macaque
single-minded family bHLH transcription factor 1
695324
Mouse
MGI:98306
20464
Rat
RGD:1309949
309888
Dog
SIM bHLH transcription factor 1
VGNC:46174
481937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIM bHLH transcription factor 1
Macaque
single-minded family bHLH transcription factor 1
Mouse
Rat
Dog
SIM bHLH transcription factor 1
Publication Statistics
PubMed Score 208.68
PubMed score by year
PubTator Score 59.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title