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Tbio
S100A12
Protein S100-A12

Protein Summary
Description
S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368737
  • ENSP00000357726
  • ENSG00000163221

Symbol
  • p6
  • CAGC
  • CGRP
  • MRP6
  • CAAF1
  • MRP-6
  • ENRAGE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.89
pathway
0.86
biological term
0.72
tissue sample
0.64
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.15   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.15   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Gene Ontology Terms (27)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (110)
1 – 10 of 110
AGER
Tchem
Novelty: 0.00062993
Score: 0.991
Data Source: STRINGDB
S100A8
Tbio
Novelty: 0.00087621
Score: 0.985
Data Source: STRINGDB
HMGB1
Tbio
Family: TF
Novelty: 0.00050302
Score: 0.955
Data Source: STRINGDB
SAA1
Tbio
Novelty: 0.00074577
Score: 0.942
Data Source: STRINGDB
S100A9
Tbio
Novelty: 0.00112347
Score: 0.931
Data Source: STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00165205
Score: 0.922
Data Source: STRINGDB
MAPK3
Tchem
Family: Kinase
Novelty: 0.0001911
Score: 0.916
Data Source: STRINGDB
MAPK1
Tchem
Family: Kinase
Novelty: 0.00046573
Score: 0.912
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00011446
Score: 0.911
Data Source: STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.00091233
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  348.15

PubMed score by year
PubTator Score  365.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer