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Tclin
ABAT
4-aminobutyrate aminotransferase, mitochondrial

Protein Summary
Description
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been fo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268251
  • ENSP00000268251
  • ENSG00000183044
  • ENST00000396600
  • ENSP00000379845
  • ENST00000425191
  • ENSP00000411916

Symbol
  • GABAT
  • GABAT
  • NPD009
  • GABA-AT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.96
kinase perturbation
0.81
molecular function
0.81
cellular component
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.9   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.9   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
vigabatrin
Rendered image for vigabatrin
Active Ligands (2)
1 – 2 of 2
4-acryloylphenol
Rendered image for 4-acryloylphenol
CPP-115
Rendered image for CPP-115
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to opioid
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to opioid
1
21.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
4-aminobutyrate aminotransferase
VGNC:13649
453903
Mouse
MGI:2443582
268860
Rat
RGD:620948
81632
Dog
4-aminobutyrate aminotransferase
VGNC:37421
479856
Horse
4-aminobutyrate aminotransferase
VGNC:14897
100051470
Species
Name
OMA
EggNOG
Inparanoid
Chimp
4-aminobutyrate aminotransferase
Mouse
Rat
Dog
4-aminobutyrate aminotransferase
Horse
4-aminobutyrate aminotransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P80404-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
Degradation of GABA (R-HSA-916853)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of GABA
Reactome
GABA synthesis, release, reuptake and degradation
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Degradation of GABA
GABA synthesis, release, reuptake and degradation
Neuronal System
Neurotransmitter release cycle
Transmission across Chemical Synapses
Gene Ontology Terms (36)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (111)
1 – 10 of 111
ARMH1
Tdark
Novelty:  3.31143233
p_int:  0.99886972
p_ni:  0.00113028
Score:  0.685
Data Source:  BioPlex,STRINGDB
ZSCAN29
Tdark
Family:  TF
Novelty:  1.70466621
p_int:  0.808496358
p_ni:  0.191503601
p_wrong:  4.1e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
SEC22C
Tdark
Novelty:  0.53697928
p_int:  0.784095876
p_ni:  0.215904124
Score:  0.465
Data Source:  BioPlex,STRINGDB
ASGR1
Tbio
Novelty:  0.00209845
p_int:  0.77888664
p_ni:  0.221113359
p_wrong:  1e-9
Score:  0.384
Data Source:  BioPlex,STRINGDB
ALDH5A1
Tclin
Family:  Enzyme
Novelty:  0.00461791
Score:  0.997
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.982
Data Source:  STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.981
Data Source:  STRINGDB
GADL1
Tbio
Family:  Enzyme
Novelty:  0.018813
Score:  0.963
Data Source:  STRINGDB
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
Score:  0.961
Data Source:  STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.959
Data Source:  STRINGDB
Publication Statistics
PubMed Score  129.90

PubMed score by year
PubTator Score  410.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer