Tclin ABAT 4-aminobutyrate aminotransferase, mitochondrial

Protein Summary

Description

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P80404
• A8K386
• Q16260
• Q8N5W2
• Q96BG2
• Q99800

Gene Name

• ABAT

Ensembl ID

• ENST00000268251
• ENSP00000268251
• ENSG00000183044
• ENST00000396600
• ENSP00000379845
• ENST00000425191
• ENSP00000411916

Symbol

• GABAT
• GABAT
• NPD009
• GABA-AT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.99
transcription factor perturbation	0.96
kinase perturbation	0.81
molecular function	0.81
cellular component	0.77

Protein Classes

PANTHER Classes

Protein / Transferase / Transaminase / 4-aminobutyrate Aminotransferase, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Transaminase / 4-aminobutyrate Aminotransferase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.9   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 294   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.9   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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ARCHS4

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Approved Drugs (1)

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1 – 1 of 1

vigabatrin

ABATTclin Enzyme

INHIBITOR :

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

4-acryloylphenol

ABATTclin Enzyme

pIC50 : 6.46

CPP-115

ABATTclin Enzyme

pKi : 5.01

Protein-Protein Interactions (111)

Explore Interacting Targets

1 – 10 of 111

• See Interactions on String-DB

ARMH1

Tdark

Novelty:  3.31143233

p_int:  0.99886972

p_ni:  0.00113028

Score:  0.685

Data Source:  BioPlex,STRINGDB

ZSCAN29

Tdark

Family:  TF

Novelty:  1.70466621

p_int:  0.808496358

p_ni:  0.191503601

p_wrong:  4.1e-8

Score:  0.19

Data Source:  BioPlex,STRINGDB

SEC22C

Tdark

Novelty:  0.53697928

p_int:  0.784095876

p_ni:  0.215904124

Score:  0.465

Data Source:  BioPlex,STRINGDB

ASGR1

Tbio

Novelty:  0.00209845

p_int:  0.77888664

p_ni:  0.221113359

p_wrong:  1e-9

Score:  0.384

Data Source:  BioPlex,STRINGDB

ALDH5A1

Tclin

Family:  Enzyme

Novelty:  0.00461791

Score:  0.997

Data Source:  STRINGDB

GAD2

Tbio

Family:  Enzyme

Novelty:  0.00058427

Score:  0.982

Data Source:  STRINGDB

GAD1

Tbio

Family:  Enzyme

Novelty:  0.00067443

Score:  0.981

Data Source:  STRINGDB

GADL1

Tbio

Family:  Enzyme

Novelty:  0.018813

Score:  0.963

Data Source:  STRINGDB

GLUL

Tchem

Family:  Enzyme

Novelty:  0.00086054

Score:  0.961

Data Source:  STRINGDB

ALDH6A1

Tbio

Family:  Enzyme

Novelty:  0.03785268

Score:  0.959

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (26)

Reactome (5)

KEGG (7)

PathwayCommons (10)

WikiPathways (4)

Degradation of GABA (R-HSA-916853)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Degradation of GABA	2 targets	R-HSA-916853
Reactome	GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Neurotransmitter release cycle	51 targets	R-HSA-112310
Reactome	Transmission across Chemical Synapses	253 targets	R-HSA-112315

Name	Explore in Pharos	Explore in Source
Degradation of GABA	2 targets	R-HSA-916853
GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Neuronal System	398 targets	R-HSA-112316
Neurotransmitter release cycle	51 targets	R-HSA-112310
Transmission across Chemical Synapses	253 targets	R-HSA-112315

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (36)

Functions (8)

Components (4)

Processes (24)

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1 – 8 of 8

GO Term	Evidence	Assigned by
pyridoxal phosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
4-aminobutyrate transaminase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
succinate-semialdehyde dehydrogenase binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
(S)-3-amino-2-methylpropionate transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
4-aminobutyrate:2-oxoglutarate transaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
iron-sulfur cluster binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
response to opioid	EFO_0008541	1	1	1		21.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
response to opioid	EFO_0008541	1		21.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Aminotransferase
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Iron
Iron-sulfur
Metal-binding
Mitochondrion

GWAS Trait Find Similar Targets

No Header	No Header
response to opioid

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	4-aminobutyrate aminotransferase	VGNC:13649	453903
Mouse	4-aminobutyrate aminotransferase	MGI:2443582	268860
Rat	4-aminobutyrate aminotransferase	RGD:620948	81632
Dog	4-aminobutyrate aminotransferase	VGNC:37421	479856
Horse	4-aminobutyrate aminotransferase	VGNC:14897	100051470

Species	Name	OMA	EggNOG	Inparanoid
Chimp	4-aminobutyrate aminotransferase
Mouse	4-aminobutyrate aminotransferase
Rat	4-aminobutyrate aminotransferase
Dog	4-aminobutyrate aminotransferase
Horse	4-aminobutyrate aminotransferase

Publication Statistics

PubMed Score 129.90

PubMed score by year

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PubTator Score 410.82

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Related Publications

Text Mined References (35)

GeneRif Annotations (12)

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PMID	Year	Title