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Tchem
DLK1
Protein delta homolog 1

Protein Summary
Description
May have a role in neuroendocrine differentiation. This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331224
  • ENSP00000331081
  • ENSG00000185559
  • ENST00000341267
  • ENSP00000340292
  • ENST00000650464
  • ENSP00000497700

Symbol
  • DLK
  • DLK
  • FA1
  • ZOG
  • pG2
  • DLK-1
  • PREF1
  • Delta1
  • Pref-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
gene perturbation
0.98
disease perturbation
0.79
biological term
0.75
small molecule perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.71   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.71   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
sunitinib
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
50.2
comparative body size at age 10, self-reported
1
1
1
10.2
response to diuretic
1
1
0
2.5
0
diastolic blood pressure change measurement
1
1
0
2.5
0
1
1
0
2.5
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
50.2
comparative body size at age 10, self-reported
1
10.2
response to diuretic
0
2.5
0
diastolic blood pressure change measurement
0
2.5
0
0
2.5
0
Pathways (21)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Reactome
Signaling by NOTCH1
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Signal Transduction
Signaling by NOTCH
Signaling by NOTCH1
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (126)
1 – 10 of 126
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
p_int: 0.999995284
p_ni: 0.000004709
p_wrong: 6e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
ANKRD13C
Tbio
Novelty: 1.5309683
p_int: 0.999991605
p_ni: 0.00000348
p_wrong: 0.000004915
Data Source: BioPlex
UBE3B
Tbio
Family: Enzyme
Novelty: 0.06274049
p_int: 0.999981741
p_ni: 0.000018258
p_wrong: 1e-9
Score: 0.241
Data Source: BioPlex,STRINGDB
TMEM94
Tdark
Novelty: 0.39746809
p_int: 0.999813527
p_ni: 0.000186471
p_wrong: 2e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
CABLES2
Tdark
Novelty: 0.35458236
p_int: 0.999547757
p_ni: 0.000162765
p_wrong: 0.000289479
Score: 0.647
Data Source: BioPlex,STRINGDB
CABLES1
Tbio
Novelty: 0.04822454
p_int: 0.998943186
p_ni: 0.000064717
p_wrong: 0.000992098
Score: 0.543
Data Source: BioPlex,STRINGDB
C2CD5
Tbio
Novelty: 0.40144687
p_int: 0.998714987
p_ni: 0.001285012
Data Source: BioPlex
LAPTM4B
Tbio
Novelty: 0.01162533
p_int: 0.99824615
p_ni: 0.001724771
p_wrong: 0.000029079
Data Source: BioPlex
SCAMP1
Tbio
Novelty: 0.03293648
p_int: 0.997861285
p_ni: 0.002138557
p_wrong: 1.58e-7
Data Source: BioPlex
MYORG
Tbio
Family: Enzyme
Novelty: 0.0478246
p_int: 0.99774997
p_ni: 0.00225003
Data Source: BioPlex
Publication Statistics
PubMed Score  532.71

PubMed score by year
PubTator Score  457.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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