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Tchem
HSD11B2
Corticosteroid 11-beta-dehydrogenase isozyme 2

Protein Summary
Description
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.87
biological term
0.86
disease
0.78
PubMedID
0.76
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.23   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 626.23   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (47)
CHEMBL373257
Rendered image for CHEMBL373257
11beta-hydroxyprogesterone
Rendered image for 11beta-hydroxyprogesterone
CHEMBL1761142
Rendered image for CHEMBL1761142
CHEMBL256515
Rendered image for CHEMBL256515
CHEMBL597063
Rendered image for CHEMBL597063
CHEMBL200513
Rendered image for CHEMBL200513
CHEMBL1911698
Rendered image for CHEMBL1911698
CHEMBL597481
Rendered image for CHEMBL597481
CHEMBL1761313
Rendered image for CHEMBL1761313
Protein-Protein Interactions (49)
CYP11B2
Tchem
Novelty:  0.00128614
Score:  0.969
Data Source:  STRINGDB
CYP11B1
Tclin
Family:  Enzyme
Novelty:  0.00195229
Score:  0.967
Data Source:  STRINGDB
CYP21A2
Tchem
Family:  Enzyme
Novelty:  0.00110959
Score:  0.964
Data Source:  STRINGDB
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
Score:  0.945
Data Source:  STRINGDB
HSD3B1
Tchem
Family:  Enzyme
Novelty:  0.0019271
Score:  0.942
Data Source:  STRINGDB
AKR1D1
Tbio
Family:  Enzyme
Novelty:  0.01264297
Score:  0.932
Data Source:  STRINGDB
NR3C2
Tclin
Family:  NR
Novelty:  0.0002199
Score:  0.836
Data Source:  STRINGDB
HPGD
Tchem
Family:  Enzyme
Novelty:  0.00348376
Score:  0.751
Data Source:  STRINGDB
HSD17B3
Tchem
Family:  Enzyme
Novelty:  0.00666322
Score:  0.723
Data Source:  STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
Score:  0.717
Data Source:  STRINGDB
Pathways (11)
Glucocorticoid biosynthesis (R-HSA-194002)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glucocorticoid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroid hormones
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Glucocorticoid biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroid hormones
Metabolism of steroids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
79
BMI-adjusted waist-hip ratio
6
4
10
78
mean corpuscular volume
1
1
1
71.9
mean reticulocyte volume
1
1
1
71.6
comparative body size at age 10, self-reported
1
1
1
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
79
BMI-adjusted waist-hip ratio
10
78
mean corpuscular volume
1
71.9
mean reticulocyte volume
1
71.6
comparative body size at age 10, self-reported
1
66.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 11-beta dehydrogenase 2
VGNC:13716
468001
Macaque
hydroxysteroid 11-beta dehydrogenase 2
574396
Mouse
MGI:104720
15484
Rat
RGD:2835
25117
Dog
hydroxysteroid 11-beta dehydrogenase 2
VGNC:41799
489758
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hydroxysteroid 11-beta dehydrogenase 2
Macaque
hydroxysteroid 11-beta dehydrogenase 2
Mouse
Rat
Dog
hydroxysteroid 11-beta dehydrogenase 2
Publication Statistics
PubMed Score 626.23
PubMed score by year
PubTator Score 568.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title