Protein Summary
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
- ENST00000332374
- ENSP00000330587
- ENSG00000205358
- MT1
- MT-0
- MT-1H
- MT-IH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
small molecule perturbation | 0.86 | ||
cell type or tissue | 0.78 | ||
protein domain | 0.73 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.59 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 23 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 188.59 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 23 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0