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Tchem
MAP3K9
Mitogen-activated protein kinase kinase kinase 9

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554752
  • ENSP00000451612
  • ENSG00000006432
  • ENST00000555993
  • ENSP00000451263

Symbol
  • MLK1
  • PRKE1
  • MLK1
  • MEKK9
  • PRKE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.97
biological process
0.86
histone modification site profile
0.77
kinase perturbation
0.76


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.94   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.94   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
midostaurin
Rendered image for midostaurin
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
1
2
26.5
intelligence
1
1
1
10.1
1
1
1
10.1
self reported educational attainment
1
1
1
10.1
waist-hip ratio
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
26.5
intelligence
1
10.1
1
10.1
self reported educational attainment
1
10.1
waist-hip ratio
1
3.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 9
467498
Macaque
mitogen-activated protein kinase kinase kinase 9
693835
Mouse
MGI:2449952
338372
Rat
RGD:1562149
500690
Dog
mitogen-activated protein kinase kinase kinase 9
VGNC:42980
490765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 9
Macaque
mitogen-activated protein kinase kinase kinase 9
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 9
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P80192-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
PathwayCommons: inoh
VEGF signaling pathway ( VEGF signaling pathway )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
PathwayCommons: inoh
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Name
Explore in Pharos
Explore in Source
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
VEGF signaling pathway ( VEGF signaling pathway )
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (30)
1 – 10 of 30
MAP2K4
Tchem
Family:  Kinase
Novelty:  0.00252847
Score:  0.945
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.938
Data Source:  STRINGDB
MAP2K6
Tchem
Family:  Kinase
Novelty:  0.00569655
Score:  0.917
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.916
Data Source:  STRINGDB
NEMP1
Tdark
Novelty:  0.37603456
Score:  0.705
Data Source:  STRINGDB
ARHGAP20
Tbio
Family:  Enzyme
Novelty:  0.16551888
Score:  0.68
Data Source:  STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
Score:  0.676
Data Source:  STRINGDB
SH3RF1
Tbio
Family:  Enzyme
Novelty:  0.01836588
Score:  0.59
Data Source:  STRINGDB
GNG7
Tbio
Novelty:  0.08478455
Score:  0.59
Data Source:  STRINGDB
SH3D19
Tbio
Novelty:  0.05352867
Score:  0.588
Data Source:  STRINGDB
Publication Statistics
PubMed Score  43.94

PubMed score by year
PubTator Score  11.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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