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Tbio
CXCL6
C-X-C motif chemokine 6

Protein Summary
Description
Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226317
  • ENSP00000226317
  • ENSG00000124875

Symbol
  • GCP2
  • SCYB6
  • GCP2
  • CKA-3
  • GCP-2
  • SCYB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
disease
0.6
kinase perturbation
0.6
biological process
0.57
molecular function
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.25   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.25   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0