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Tbio
CCL7
C-C motif chemokine 7

Protein Summary
Description
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378569
  • ENSP00000367832
  • ENSG00000108688

Symbol
  • MCP3
  • SCYA6
  • SCYA7
  • FIC
  • MARC
  • MCP3
  • NC28
  • MCP-3
  • SCYA6
  • SCYA7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.74
cell type or tissue
0.73
molecular function
0.63
PubMedID
0.62
disease
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.41   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 634   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.41   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 634   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 7
VGNC:9169
454579
Mouse
MGI:99512
20306
Rat
RGD:1359152
287561
Dog
C-C motif chemokine ligand 7
VGNC:52022
491148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 7
Mouse
Rat
Dog
C-C motif chemokine ligand 7
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P80098-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
IL-17 signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
IL-17 signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Gene Ontology Terms (29)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (123)
1 – 10 of 123
CCR2
Tchem
Family: GPCR
Novelty: 0.0006525
Score: 0.985
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.98
Data Source: STRINGDB
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.956
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.923
Data Source: STRINGDB
CXCL6
Tbio
Novelty: 0.01019922
Score: 0.9
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.887
Data Source: STRINGDB
CXCR3
Tchem
Family: GPCR
Novelty: 0.00100538
Score: 0.875
Data Source: STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.837
Data Source: STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.0002811
Score: 0.821
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.814
Data Source: STRINGDB
Publication Statistics
PubMed Score  446.41

PubMed score by year
PubTator Score  348.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer