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Tbio
CCL8
C-C motif chemokine 8

Protein Summary
Description
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8. This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394620
  • ENSP00000378118
  • ENSG00000108700

Symbol
  • MCP2
  • SCYA10
  • SCYA8
  • HC14
  • MCP2
  • MCP-2
  • SCYA8
  • SCYA10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
molecular function
0.86
phenotype
0.76
disease
0.7
biological process
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.21   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.21   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Gene Ontology Terms (32)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (92)
1 – 10 of 92
CCR3
Tchem
Family: GPCR
Novelty: 0.00249792
Score: 0.976
Data Source: STRINGDB
CCR2
Tchem
Family: GPCR
Novelty: 0.00080179
Score: 0.962
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00028298
Score: 0.945
Data Source: STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00293956
Score: 0.938
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00051044
Score: 0.903
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00009183
Score: 0.896
Data Source: STRINGDB
XCR1
Tbio
Family: GPCR
Novelty: 0.01497998
Score: 0.87
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00107245
Score: 0.846
Data Source: STRINGDB
CCR10
Tchem
Family: GPCR
Novelty: 0.02210897
Score: 0.836
Data Source: STRINGDB
CXCL2
Tbio
Novelty: 0.00304903
Score: 0.827
Data Source: STRINGDB
Publication Statistics
PubMed Score  146.21

PubMed score by year
PubTator Score  130.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKR
1-70
GKEVCADPKERWVRDSMKHLDQIFQNLKP
70-99
MKVSAALLCLLLMAATFSPQGLAQPDSVSIPITCCFNVINRKIPIQRLESYTRITNIQCPKEAVIFKTKRGKEVCADPKERWVRDSMKHLDQIFQNLKP