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Tbio
ADARB1
Double-stranded RNA-specific editase 1

Protein Summary
Description
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348831
  • ENSP00000015877
  • ENSG00000197381
  • ENST00000360697
  • ENSP00000353920
  • ENST00000389863
  • ENSP00000374513
  • ENST00000437626
  • ENSP00000414600
  • ENST00000492414
  • ENSP00000436367
  • ENST00000496664
  • ENSP00000435381
  • ENST00000629643
  • ENSP00000486475

Symbol
  • ADAR2
  • DRADA2
  • RED1
  • RED1
  • ADAR2
  • DRABA2
  • DRADA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
microRNA
0.86
transcription factor perturbation
0.84
disease perturbation
0.83
biological process
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.91   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.91   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.999960106
p_ni:  0.000039872
p_wrong:  2.2e-8
Score:  0.253
Data Source:  BioPlex,STRINGDB
ADAL
Tbio
Family:  Enzyme
Novelty:  0.02192886
Score:  0.881
Data Source:  STRINGDB
STAU1
Tbio
Novelty:  0.00565778
Score:  0.808
Data Source:  STRINGDB
EIF2AK2
Tchem
Family:  Kinase
Novelty:  0.00736681
Score:  0.801
Data Source:  STRINGDB
STRBP
Tbio
Novelty:  0.00919158
Score:  0.799
Data Source:  STRINGDB
PRKRA
Tbio
Family:  Kinase
Novelty:  0.02115618
Score:  0.796
Data Source:  STRINGDB
ZMAT4
Tdark
Novelty:  0.31281969
Score:  0.794
Data Source:  STRINGDB
TARBP2
Tbio
Novelty:  0.01485994
Score:  0.794
Data Source:  STRINGDB
ZNF346
Tbio
Novelty:  0.00204191
Score:  0.782
Data Source:  STRINGDB
NKRF
Tbio
Novelty:  0.00080379
Score:  0.771
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
C6 deamination of adenosine (R-HSA-75102)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
C6 deamination of adenosine
Reactome
Formation of editosomes by ADAR proteins
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: A to I Conversion
Name
Explore in Pharos
Explore in Source
C6 deamination of adenosine
Formation of editosomes by ADAR proteins
Metabolism of RNA
mRNA Editing
mRNA Editing: A to I Conversion
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
1
4
76.9
body height
1
1
1
70.5
smoking status measurement
1
1
1
46.9
self reported educational attainment
1
1
1
46.1
smoking behaviour measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
76.9
body height
1
70.5
smoking status measurement
1
46.9
self reported educational attainment
1
46.1
smoking behaviour measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase, RNA specific B1
474045
Macaque
adenosine deaminase, RNA specific B1
722016
Mouse
MGI:891999
110532
Rat
RGD:2033
25367
Dog
adenosine deaminase, RNA specific B1
VGNC:53019
487809
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adenosine deaminase, RNA specific B1
Macaque
adenosine deaminase, RNA specific B1
Mouse
Rat
Dog
adenosine deaminase, RNA specific B1
Publication Statistics
PubMed Score 174.91
PubMed score by year
PubTator Score 275.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title