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Tbio
CRADD
Death domain-containing protein CRADD

Protein Summary
Description
Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253). This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332896
  • ENSP00000327647
  • ENSG00000169372
  • ENST00000542893
  • ENSP00000439068
  • ENST00000551065
  • ENSP00000448425

Symbol
  • RAIDD
  • MRT34
  • RAIDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor binding site profile
0.91
histone modification site profile
0.84
biological process
0.78
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.52   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 504   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.52   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 504   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
CASP2
Tchem
Family:  Enzyme
Novelty:  0.00189892
Score:  0.999
Data Source:  Reactome,STRINGDB
PIDD1
Tbio
Novelty:  0.01397556
Score:  0.998
Data Source:  Reactome,STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.968
Data Source:  STRINGDB
FADD
Tbio
Novelty:  0.00137968
Score:  0.961
Data Source:  STRINGDB
TRADD
Tbio
Novelty:  0.00560091
Score:  0.96
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.96
Data Source:  STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
Score:  0.956
Data Source:  STRINGDB
BIRC3
Tchem
Novelty:  0.00189613
Score:  0.927
Data Source:  STRINGDB
BID
Tbio
Novelty:  0.01264688
Score:  0.923
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (143)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Caspase Activators and Caspases
Reactome
TP53 Regulates Transcription of Cell Death Genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Cell Death Genes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
9
11
98.2
appendicular lean mass
3
3
5
95.2
BMI-adjusted hip circumference
3
16
19
93.5
heel bone mineral density
3
3
5
81.4
waist-hip ratio
3
2
3
67.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
11
98.2
appendicular lean mass
5
95.2
BMI-adjusted hip circumference
19
93.5
heel bone mineral density
5
81.4
waist-hip ratio
3
67.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CASP2 and RIPK1 domain containing adaptor with death domain
VGNC:8384
452128
Macaque
CASP2 and RIPK1 domain containing adaptor with death domain
711165
Mouse
MGI:1336168
12905
Dog
CASP2 and RIPK1 domain containing adaptor with death domain
VGNC:39591
482604
Cow
CASP2 and RIPK1 domain containing adaptor with death domain
615788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CASP2 and RIPK1 domain containing adaptor with death domain
Macaque
CASP2 and RIPK1 domain containing adaptor with death domain
Mouse
Dog
CASP2 and RIPK1 domain containing adaptor with death domain
Cow
CASP2 and RIPK1 domain containing adaptor with death domain
Publication Statistics
PubMed Score 34.52
PubMed score by year
PubTator Score 18.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title