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Tbio
CCL20
C-C motif chemokine 20

Protein Summary
Description
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358813
  • ENSP00000351671
  • ENSG00000115009
  • ENST00000409189
  • ENSP00000386273

Symbol
  • LARC
  • MIP3A
  • SCYA20
  • CKb4
  • LARC
  • ST38
  • MIP3A
  • Exodus
  • MIP-3a
  • SCYA20
  • MIP-3-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
virus perturbation
0.99
biological term
0.92
small molecule perturbation
0.81
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1533.33   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 633   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1533.33   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (379)
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
Score:  0.994
Data Source:  Reactome,STRINGDB
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.988
Data Source:  STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
Score:  0.988
Data Source:  STRINGDB
CXCL11
Tbio
Novelty:  0.00077765
Score:  0.986
Data Source:  STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.983
Data Source:  STRINGDB
CXCL5
Tbio
Novelty:  0.00286795
Score:  0.98
Data Source:  STRINGDB
CXCL2
Tbio
Novelty:  0.00201175
Score:  0.979
Data Source:  STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.979
Data Source:  STRINGDB
CCL5
Tchem
Novelty:  0.00032607
Score:  0.979
Data Source:  STRINGDB
CXCL3
Tbio
Novelty:  0.01001656
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (51)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
2
2
0
1.1
88.8
asthma
4
3
0
1
81.5
allergic disease
3
2
2
1
69.4
age at onset
2
1
1
1.1
66.7
3
3
0
1
66.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.1
88.8
asthma
0
1
81.5
allergic disease
2
1
69.4
age at onset
1
1.1
66.7
0
1
66.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 20
VGNC:125
459991
Macaque
C-C motif chemokine ligand 20
574182
Mouse
MGI:1329031
20297
Rat
RGD:3646
29538
Dog
C-C motif chemokine ligand 20
VGNC:38884
448790
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine ligand 20
Macaque
C-C motif chemokine ligand 20
Mouse
Rat
Dog
C-C motif chemokine ligand 20
Publication Statistics
PubMed Score 1533.33
PubMed score by year
PubTator Score 499.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title