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Tbio
IL13RA1
Interleukin-13 receptor subunit alpha-1

Protein Summary
Description
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371642
  • ENSP00000360705
  • ENSG00000131724
  • ENST00000371666
  • ENSP00000360730

Symbol
  • IL13R
  • IL13RA
  • NR4
  • CT19
  • CD213A1
  • IL-13Ra
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
0.88
kinase perturbation
0.81
PubMedID
0.81
histone modification site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.84   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.84   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
80.3
1
1
0
1.1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
80.3
0
1.1
62.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 13 receptor subunit alpha 1
VGNC:6432
735671
Mouse
MGI:105052
16164
Rat
RGD:628741
252963
Dog
interleukin 13 receptor subunit alpha 1
VGNC:41937
403623
Horse
interleukin 13 receptor subunit alpha 1
VGNC:18997
100055312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 13 receptor subunit alpha 1
Mouse
Rat
Dog
interleukin 13 receptor subunit alpha 1
Horse
interleukin 13 receptor subunit alpha 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78552-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (96)
1 – 10 of 96
MAP4K3
Tchem
Family:  Kinase
Novelty:  0.04596429
p_int:  0.999999599
p_ni:  3.7e-7
p_wrong:  3.1e-8
Score:  0.622
Data Source:  BioPlex,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999994164
p_ni:  0.00000187
p_wrong:  0.000003966
Score:  0.186
Data Source:  BioPlex,STRINGDB
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.999727986
p_ni:  0.000010858
p_wrong:  0.000261156
Score:  0.189
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.804772935
p_ni:  0.195227065
Score:  0.189
Data Source:  BioPlex,STRINGDB
IL4R
Tclin
Novelty:  0.00359183
Score:  0.996
Data Source:  Reactome,STRINGDB
IL13
Tbio
Novelty:  0.00021435
Score:  0.996
Data Source:  Reactome,STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.992
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.956
Data Source:  Reactome,STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.951
Data Source:  Reactome,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.949
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  21.84

PubMed score by year
PubTator Score  67.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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