Tbio IL13RA1 Interleukin-13 receptor subunit alpha-1

Protein Summary

Description

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity. The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78552
• O95646
• Q5JSL4
• Q99656
• Q9UDY5
• IL-13 receptor subunit alpha-1

Gene Name

• IL13RA1

Ensembl ID

• ENST00000371642
• ENSP00000360705
• ENSG00000131724
• ENST00000371666
• ENSP00000360730

Symbol

• IL13R
• IL13RA
• NR4
• CT19
• CD213A1
• IL-13Ra

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
virus perturbation	0.88
kinase perturbation	0.81
PubMedID	0.81
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Interleukin-13 Receptor Subunit Alpha-1

Protein / Defense/immunity Protein / Interleukin-13 Receptor Subunit Alpha-1

DTO Classes

Protein / Signaling / Cytokine / Interleukin-13 Receptor Subunit Alpha-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.23   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 496   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.23   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0