Tbio NTHL1 Endonuclease III-like protein 1

Protein Summary

Description

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P78549
• Q1MVR1
• Q99566
• Q99794
• Q9BPX2
• hNTH1

Gene Name

• NTHL1

Ensembl ID

• ENST00000219066
• ENSP00000219066
• ENSG00000065057

Symbol

• NTH1
• OCTS3
• FAP3
• NTH1
• OCTS3
• hNTH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
histone modification site profile	0.87
protein domain	0.85
cell type or tissue	0.76
transcription factor binding site profile	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endodeoxyribonuclease / Endonuclease Iii-like Protein 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Endodeoxyribonuclease / Endonuclease Iii-like Protein 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Glycosylase / Endonuclease Iii-like Protein 1

Protein / Hydrolase / Glycosidase / Endonuclease Iii-like Protein 1

DTO Classes

Protein / Enzyme / Hydrolase / Glycosylase / Dna Glycosylase / Endonuclease Iii-like Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.56   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.56   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0