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Tbio
NTHL1
Endonuclease III-like protein 1

Protein Summary
Description
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption. The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219066
  • ENSP00000219066
  • ENSG00000065057

Symbol
  • NTH1
  • OCTS3
  • FAP3
  • NTH1
  • OCTS3
  • hNTH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
histone modification site profile
0.87
protein domain
0.85
cell type or tissue
0.76
transcription factor binding site profile
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.45   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.45   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
MINDY3
Tbio
Novelty:  0.02865765
p_int:  0.811473041
p_ni:  0.000028092
p_wrong:  0.188498867
Score:  0.3
Data Source:  BioPlex,STRINGDB
APEX1
Tchem
Family:  Enzyme
Novelty:  0.00037532
Score:  0.997
Data Source:  Reactome,STRINGDB
OGG1
Tchem
Family:  Enzyme
Novelty:  0.00074509
Score:  0.953
Data Source:  STRINGDB
NEIL1
Tbio
Family:  Enzyme
Novelty:  0.00683956
Score:  0.904
Data Source:  STRINGDB
FEN1
Tchem
Family:  Enzyme
Novelty:  0.00082515
Score:  0.898
Data Source:  STRINGDB
UNG
Tbio
Family:  Enzyme
Novelty:  0.00268354
Score:  0.893
Data Source:  STRINGDB
MUTYH
Tbio
Family:  Enzyme
Novelty:  0.00137239
Score:  0.891
Data Source:  STRINGDB
NEIL3
Tbio
Family:  Enzyme
Novelty:  0.02068317
Score:  0.875
Data Source:  STRINGDB
NEIL2
Tbio
Family:  Enzyme
Novelty:  0.01124634
Score:  0.874
Data Source:  STRINGDB
APEX2
Tbio
Family:  Enzyme
Novelty:  0.04076395
Score:  0.828
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged pyrimidine
Reactome
DNA Repair
Reactome
Defective Base Excision Repair Associated with NTHL1
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged pyrimidine
DNA Repair
Defective Base Excision Repair Associated with NTHL1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
3
82.9
appendicular lean mass
3
1
3
81.2
serum gamma-glutamyl transferase measurement
1
1
1
81
BMI-adjusted waist circumference
2
3
4
80.2
2
3
0
1.1
77.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
82.9
appendicular lean mass
3
81.2
serum gamma-glutamyl transferase measurement
1
81
BMI-adjusted waist circumference
4
80.2
0
1.1
77.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nth like DNA glycosylase 1
VGNC:13754
468087
Macaque
nth like DNA glycosylase 1
694848
Mouse
MGI:1313275
18207
Rat
RGD:1309289
29541
Dog
nth like DNA glycosylase 1
VGNC:44004
610981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nth like DNA glycosylase 1
Macaque
nth like DNA glycosylase 1
Mouse
Rat
Dog
nth like DNA glycosylase 1
Publication Statistics
PubMed Score 123.45
PubMed score by year
PubTator Score 60.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title