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Tbio
ELF3
ETS-related transcription factor Elf-3

Protein Summary
Description
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359651
  • ENSP00000352673
  • ENSG00000163435
  • ENST00000367283
  • ENSP00000356252
  • ENST00000367284
  • ENSP00000356253

Symbol
  • ERT
  • ESX
  • JEN
  • ERT
  • ESX
  • EPR-1
  • ESE-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
molecular function
0.88
PubMedID
0.86
transcription factor binding site profile
0.83
biological process
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.55   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.55   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.944
Data Source:  STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
Score:  0.939
Data Source:  Reactome,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.938
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.935
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.919
Data Source:  STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.914
Data Source:  STRINGDB
AGO3
Tbio
Novelty:  0.01664154
Score:  0.901
Data Source:  STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
Score:  0.9
Data Source:  STRINGDB
TNRC6A
Tbio
Novelty:  0.00505282
Score:  0.9
Data Source:  STRINGDB
AGO2
Tbio
Novelty:  0.00057003
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Pre-NOTCH Expression and Processing (R-HSA-1912422)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Pre-NOTCH Expression and Processing
Reactome
Pre-NOTCH Transcription and Translation
Reactome
Signal Transduction
Reactome
Signaling by NOTCH
Name
Explore in Pharos
Explore in Source
Pre-NOTCH Expression and Processing
Pre-NOTCH Transcription and Translation
Signal Transduction
Signaling by NOTCH
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
1
1
1
65.3
FEV/FEC ratio
1
1
1
42.3
neuroticism measurement
2
1
0
5.7
28.1
matrix metalloproteinase 7 measurement
1
1
1
26.5
appendicular lean mass
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
butyrylcholinesterase measurement
1
65.3
FEV/FEC ratio
1
42.3
neuroticism measurement
0
5.7
28.1
matrix metalloproteinase 7 measurement
1
26.5
appendicular lean mass
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
E74 like ETS transcription factor 3
VGNC:8318
739176
Macaque
E74 like ETS transcription factor 3
707937
Mouse
MGI:1101781
13710
Rat
RGD:1310687
304815
Dog
E74 like ETS transcription factor 3
VGNC:40300
490235
Species
Name
OMA
EggNOG
Inparanoid
Chimp
E74 like ETS transcription factor 3
Macaque
E74 like ETS transcription factor 3
Mouse
Rat
Dog
E74 like ETS transcription factor 3
Publication Statistics
PubMed Score 394.55
PubMed score by year
PubTator Score 243.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title