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Tbio
BTG2
Protein BTG2

Protein Summary
Description
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth. The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein is involved in the regulation of the G1/S transition of the cell cycle. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290551
  • ENSP00000290551
  • ENSG00000159388
  • ENST00000475157
  • ENSP00000433553

Symbol
  • PC3
  • PC3
  • APRO1
  • TIS21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
small molecule perturbation
0.99
biological process
0.95
disease perturbation
0.95
PubMedID
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.31   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.31   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
90.5
mean corpuscular volume
1
2
2
90.5
reticulocyte measurement
2
2
2
75.1
reticulocyte count
2
2
2
63.6
mean corpuscular hemoglobin concentration
1
1
1
44.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
90.5
mean corpuscular volume
2
90.5
reticulocyte measurement
2
75.1
reticulocyte count
2
63.6
mean corpuscular hemoglobin concentration
1
44.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BTG anti-proliferation factor 2
VGNC:4976
740912
Macaque
BTG anti-proliferation factor 2
703168
Mouse
MGI:108384
12227
Rat
RGD:2225
29619
Dog
BTG anti-proliferation factor 2
VGNC:54278
488559
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BTG anti-proliferation factor 2
Macaque
BTG anti-proliferation factor 2
Mouse
Rat
Dog
BTG anti-proliferation factor 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78543-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Cycle Genes
Reactome
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Cycle Genes
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Protein-Protein Interactions (88)
1 – 10 of 88
CNOT7
Tchem
Novelty:  0.04551853
Score:  0.987
Data Source:  STRINGDB
PRMT1
Tchem
Family:  Epigenetic
Novelty:  0.0032916
Score:  0.982
Data Source:  STRINGDB
CNOT8
Tbio
Novelty:  0.01700084
Score:  0.979
Data Source:  STRINGDB
HOXB9
Tbio
Family:  TF
Novelty:  0.01591519
Score:  0.975
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.974
Data Source:  STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
Score:  0.964
Data Source:  STRINGDB
CCND1
Tchem
Novelty:  0.0001186
Score:  0.963
Data Source:  STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
Score:  0.958
Data Source:  STRINGDB
CNOT6
Tbio
Novelty:  0.03605299
Score:  0.928
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.923
Data Source:  STRINGDB
Publication Statistics
PubMed Score  219.31

PubMed score by year
PubTator Score  136.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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