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Tbio
BLOC1S1
Biogenesis of lysosome-related organelles complex 1 subunit 1

Protein Classes
Protein Summary
Description
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000548925
  • ENSP00000447537
  • ENSG00000135441

Symbol
  • BLOS1
  • GCN5L1
  • RT14
  • RT14
  • BLOS1
  • MICoA
  • BORCS1
  • GCN5L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
cellular component
0.78
interacting protein
0.75
transcription factor binding site profile
0.72
transcription factor
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.1   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.1   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1195276
14533
Rat
RGD:1307564
288785
Dog
biogenesis of lysosomal organelles complex 1 subunit 1
106557465
Horse
biogenesis of lysosomal organelles complex 1 subunit 1
100051308
Cow
biogenesis of lysosomal organelles complex 1 subunit 1
615149
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
biogenesis of lysosomal organelles complex 1 subunit 1
Horse
biogenesis of lysosomal organelles complex 1 subunit 1
Cow
biogenesis of lysosomal organelles complex 1 subunit 1
Pathways (6)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Lysosome Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Lysosome Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Gene Ontology Terms (17)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
GOC
Protein-Protein Interactions (83)
1 – 10 of 83
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.9999999
p_ni: 1e-7
Score: 0.995
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.999999815
p_ni: 1.73e-7
p_wrong: 1.2e-8
Score: 0.966
Data Source: BioPlex,STRINGDB
BORCS7
Tbio
Novelty: 0.14135922
p_int: 0.999999565
p_ni: 4.35e-7
Score: 0.957
Data Source: BioPlex,STRINGDB
BCAS4
Tbio
Novelty: 0.11759439
p_int: 0.99999615
p_ni: 0.00000385
Score: 0.896
Data Source: BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty: 0.01845286
p_int: 0.999995355
p_ni: 0.000004645
Score: 0.985
Data Source: BioPlex,STRINGDB
TEX35
Tdark
Novelty: 0.5605055
p_int: 0.999898537
p_ni: 0.000101414
p_wrong: 4.9e-8
Score: 0.653
Data Source: BioPlex,STRINGDB
TNFRSF8
Tclin
Novelty: 0.00030231
p_int: 0.999577606
p_ni: 0.000390856
p_wrong: 0.000031539
Score: 0.173
Data Source: BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.99873492
p_ni: 0.001264925
p_wrong: 1.55e-7
Score: 0.359
Data Source: BioPlex,STRINGDB
IKBIP
Tbio
Family: Enzyme
Novelty: 0.18707639
p_int: 0.998657872
p_ni: 0.000317068
p_wrong: 0.00102506
Score: 0.194
Data Source: BioPlex,STRINGDB
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.997825822
p_ni: 0.002173132
p_wrong: 0.000001046
Score: 0.557
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  26.10

PubMed score by year
PubTator Score  9.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer