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Tchem
ADAM17
Disintegrin and metalloproteinase domain-containing protein 17

Protein Summary
Description
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form (PubMed:9034191). Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein (PubMed:12441351). Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT) (PubMed:24226769). Plays a role in the proteolytic processing of ACE2 (PubMed:24227843). This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic proce ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310823
  • ENSP00000309968
  • ENSG00000151694
  • ENST00000497134
  • ENSP00000418728

Symbol
  • CSVP
  • TACE
  • CSVP
  • TACE
  • NISBD
  • ADAM18
  • CD156B
  • NISBD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase
0.95
virus perturbation
0.95
biological term
0.9
molecular function
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 736.08   (req: < 5)
Gene RIFs: 339   (req: <= 3)
Antibodies: 877   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 736.08   (req: >= 5)
Gene RIFs: 339   (req: > 3)
Antibodies: 877   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1190
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
prednisolone
chemical structure image
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
80.6
birth weight
2
2
2
73.4
tumor necrosis factor receptor 1 measurement
1
1
1
51.1
parental genotype effect measurement
1
1
1
30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
80.6
birth weight
2
73.4
tumor necrosis factor receptor 1 measurement
1
51.1
parental genotype effect measurement
1
30
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 17
VGNC:6
459018
Macaque
ADAM metallopeptidase domain 17
694429
Mouse
MGI:1096335
11491
Rat
RGD:620404
57027
Dog
ADAM metallopeptidase domain 17
VGNC:37576
475662
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 17
Macaque
ADAM metallopeptidase domain 17
Mouse
Rat
Dog
ADAM metallopeptidase domain 17
Protein Structure (23 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78536-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 23
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (101)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Collagen degradation
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Collagen degradation
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Gene Ontology Terms (58)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
ARUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (170)
1 – 10 of 170
SDK2
Tdark
Novelty: 0.08867136
p_int: 0.992623704
p_ni: 0.00561797
p_wrong: 0.001758326
Score: 0.232
Data Source: BioPlex,STRINGDB
LMAN2L
Tbio
Novelty: 0.04364985
p_int: 0.959660516
p_ni: 0.040339484
Score: 0.177
Data Source: BioPlex,STRINGDB
INSL5
Tbio
Novelty: 0.04351334
p_int: 0.903584409
p_ni: 0.096415591
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.832010753
p_ni: 0.167989247
Data Source: BioPlex
LRRC3
Tdark
Novelty: 0.13484671
p_int: 0.820850728
p_ni: 0.001593841
p_wrong: 0.17755543
Score: 0.31
Data Source: BioPlex,STRINGDB
CCL17
Tbio
Novelty: 0.00160208
p_int: 0.759441904
p_ni: 0.240558096
Score: 0.19
Data Source: BioPlex,STRINGDB
TIMP3
Tbio
Family: Enzyme
Novelty: 0.00134742
Score: 0.993
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.984
Data Source: STRINGDB
EGF
Tbio
Novelty: 0.00010809
Score: 0.979
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.979
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  736.08

PubMed score by year
PubTator Score  1258.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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