PRKDC
DNA-dependent protein kinase catalytic subunit
You are using an outdated browser. Please upgrade your browser to improve your experience.
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
protein domain | 0.99 | ||
molecular function | 0.98 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytosolic sensors of pathogen-associated DNA | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | E3 ubiquitin ligases ubiquitinate target proteins | ||||
Reactome | IRF3-mediated induction of type I IFN | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytosolic sensors of pathogen-associated DNA | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
E3 ubiquitin ligases ubiquitinate target proteins | ||||
IRF3-mediated induction of type I IFN | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 2 | 3 | 88.4 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 84.1 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 81.9 | |||||
basophil percentage of leukocytes | 1 | 2 | 2 | 78.6 | |||||
mean corpuscular volume | 1 | 1 | 1 | 75 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 3 | 88.4 | |||||
eosinophil percentage of leukocytes | 3 | 84.1 | |||||
mean reticulocyte volume | 1 | 81.9 | |||||
basophil percentage of leukocytes | 2 | 78.6 | |||||
mean corpuscular volume | 1 | 75 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | protein kinase, DNA-activated, catalytic polypeptide | 464165 | ||||||
Macaque | protein kinase, DNA-activated, catalytic polypeptide | 708029 | ||||||
Mouse | MGI:104779 | 19090 | ||||||
Rat | RGD:1308982 | 360748 | ||||||
Dog | protein kinase, DNA-activated, catalytic polypeptide | VGNC:44989 | 474176 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | protein kinase, DNA-activated, catalytic polypeptide | |||||
Macaque | protein kinase, DNA-activated, catalytic polypeptide | |||||
Mouse | ||||||
Rat | ||||||
Dog | protein kinase, DNA-activated, catalytic polypeptide | |||||
PMID | Year | Title |
---|