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Tchem
PRKDC
DNA-dependent protein kinase catalytic subunit

Protein Summary
Description
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314191
  • ENSP00000313420
  • ENSG00000253729
  • ENST00000338368
  • ENSP00000345182

Symbol
  • HYRC
  • HYRC1
  • HYRC
  • p350
  • DNAPK
  • DNPK1
  • HYRC1
  • IMD26
  • XRCC7
  • DNAPKc
  • DNA-PKC
  • DNA-PKcs
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
protein domain
0.99
molecular function
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.38   (req: < 5)
Gene RIFs: 265   (req: <= 3)
Antibodies: 1451   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1060.38   (req: >= 5)
Gene RIFs: 265   (req: > 3)
Antibodies: 1451   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 176
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0