PRKDC
DNA-dependent protein kinase catalytic subunit
Protein Summary
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat ...more
- ENST00000314191
- ENSP00000313420
- ENSG00000253729
- ENST00000338368
- ENSP00000345182
- HYRC
- HYRC1
- HYRC
- p350
- DNAPK
- DNPK1
- HYRC1
- IMD26
- XRCC7
- DNAPKc
- DNA-PKC
- DNA-PKcs
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
protein domain | 0.99 | ||
molecular function | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 985.7 (req: < 5)
Gene RIFs: 265 (req: <= 3)
Antibodies: 1451 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 985.7 (req: >= 5)
Gene RIFs: 265 (req: > 3)
Antibodies: 1451 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 53
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 169
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (169)
Protein-Protein Interactions (369)
EPHA1
Family: Kinase
Novelty: 0.00136672
p_int: 0.970813602
p_ni: 0.029186398
Score: 0.236
Data Source: BioPlex,STRINGDB
PPP6R2
Family: Enzyme
Novelty: 0.12886225
p_int: 0.941070431
p_ni: 0.058929569
Score: 0.566
Data Source: BioPlex,STRINGDB
LPAR4
Family: GPCR
Novelty: 0.02200758
p_int: 0.879562939
p_ni: 0.120437061
Score: 0.19
Data Source: BioPlex,STRINGDB
DCLRE1C
Novelty: 0.01064408
p_int: 0.783080242
p_ni: 0.216919758
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (29)
Reactome (12)
KEGG (2)
PathwayCommons (4)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytosolic sensors of pathogen-associated DNA | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | E3 ubiquitin ligases ubiquitinate target proteins | ||||
Reactome | IRF3-mediated induction of type I IFN | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytosolic sensors of pathogen-associated DNA | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
E3 ubiquitin ligases ubiquitinate target proteins | ||||
IRF3-mediated induction of type I IFN | ||||
Viral Interactions (0)
Gene Ontology Terms (64)
Functions (9)
Components (11)
Processes (44)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Direct Assay (IDA) | CACAO | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 2 | 3 | 88.4 | |||||
eosinophil percentage of leukocytes | 2 | 2 | 3 | 84.1 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 81.9 | |||||
basophil percentage of leukocytes | 1 | 2 | 2 | 78.6 | |||||
mean corpuscular volume | 1 | 1 | 1 | 75 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 3 | 88.4 | |||||
eosinophil percentage of leukocytes | 3 | 84.1 | |||||
mean reticulocyte volume | 1 | 81.9 | |||||
basophil percentage of leukocytes | 2 | 78.6 | |||||
mean corpuscular volume | 1 | 75 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protein kinase, DNA-activated, catalytic polypeptide | 464165 | ||||||
Macaque | protein kinase, DNA-activated, catalytic polypeptide | 708029 | ||||||
Mouse | MGI:104779 | 19090 | ||||||
Rat | RGD:1308982 | 360748 | ||||||
Dog | protein kinase, DNA-activated, catalytic polypeptide | VGNC:44989 | 474176 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protein kinase, DNA-activated, catalytic polypeptide | |||||
Macaque | protein kinase, DNA-activated, catalytic polypeptide | |||||
Mouse | ||||||
Rat | ||||||
Dog | protein kinase, DNA-activated, catalytic polypeptide | |||||
Publication Statistics
PubMed Score 985.70
PubMed score by year
PubTator Score 1068.05
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (387)
GeneRif Annotations (265)
Items per page:
0 of 0
PMID | Year | Title |
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