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Tchem
PRKDC
DNA-dependent protein kinase catalytic subunit

Protein Classes
Protein Summary
Description
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314191
  • ENSP00000313420
  • ENSG00000253729
  • ENST00000338368
  • ENSP00000345182

Symbol
  • HYRC
  • HYRC1
  • HYRC
  • p350
  • DNAPK
  • DNPK1
  • HYRC1
  • IMD26
  • XRCC7
  • DNAPKc
  • DNA-PKC
  • DNA-PKcs
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
protein domain
0.99
molecular function
0.98


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 963.16   (req: < 5)
Gene RIFs: 265   (req: <= 3)
Antibodies: 1451   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 963.16   (req: >= 5)
Gene RIFs: 265   (req: > 3)
Antibodies: 1451   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 146
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (146)
1 – 10 of 146
CHEMBL1081312
chemical structure image
CHEMBL1765602
chemical structure image
CHEMBL1615189
chemical structure image
CHEMBL393525
chemical structure image
CHEMBL573339,CHEMBL538346
chemical structure image
CHEMBL428496
chemical structure image
CHEMBL1738719
chemical structure image
CHEMBL1914743
chemical structure image
CHEMBL1241578
chemical structure image
CHEMBL3797933
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
68
hemoglobin measurement
2
2
2
59.6
body height
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
68
hemoglobin measurement
2
59.6
body height
1
6.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase, DNA-activated, catalytic polypeptide
464165
Macaque
protein kinase, DNA-activated, catalytic polypeptide
708029
Mouse
MGI:104779
19090
Rat
RGD:1308982
360748
Dog
protein kinase, DNA-activated, catalytic polypeptide
VGNC:44989
474176
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase, DNA-activated, catalytic polypeptide
Macaque
protein kinase, DNA-activated, catalytic polypeptide
Mouse
Rat
Dog
protein kinase, DNA-activated, catalytic polypeptide
Protein Structure (3 Structures, 15 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (29)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
IRF3-mediated induction of type I IFN
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
DNA Double-Strand Break Repair
DNA Repair
E3 ubiquitin ligases ubiquitinate target proteins
IRF3-mediated induction of type I IFN
Gene Ontology Terms (64)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (369)
1 – 10 of 369
EPHA1
Tchem
Family: Kinase
Novelty: 0.00136672
p_int: 0.970813602
p_ni: 0.029186398
Score: 0.236
Data Source: BioPlex,STRINGDB
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.941070431
p_ni: 0.058929569
Score: 0.566
Data Source: BioPlex,STRINGDB
LPAR4
Tchem
Family: GPCR
Novelty: 0.02200758
p_int: 0.879562939
p_ni: 0.120437061
Score: 0.19
Data Source: BioPlex,STRINGDB
DCLRE1C
Tbio
Novelty: 0.01064408
p_int: 0.783080242
p_ni: 0.216919758
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
XRCC4
Tbio
Novelty: 0.00305644
Score: 0.999
Data Source: Reactome,STRINGDB
XRCC6
Tbio
Novelty: 0.00127955
Score: 0.999
Data Source: Reactome,STRINGDB
XRCC5
Tbio
Novelty: 0.00150735
Score: 0.999
Data Source: Reactome,STRINGDB
H2AFX
Tbio
Novelty: 0.00048694
Score: 0.993
Data Source: STRINGDB
NHEJ1
Tbio
Novelty: 0.00773499
Score: 0.992
Data Source: Reactome,STRINGDB
LIG4
Tbio
Family: Enzyme
Novelty: 0.00412993
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  963.16

PubMed score by year
PubTator Score  1068.05

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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