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Tbio
KCNJ10
ATP-sensitive inward rectifier potassium channel 10

Protein Summary
Description
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules. This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368089
  • ENSP00000357068
  • ENSG00000177807
  • ENST00000638728
  • ENSP00000492619
  • ENST00000638868
  • ENSP00000491250
  • ENST00000644903
  • ENSP00000495557

Symbol
  • KIR1.2
  • KIR4.1
  • SESAME
  • BIRK-10
  • KCNJ13-PEN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
microRNA
0.88
biological process
0.87
protein complex
0.74
gene perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.36   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 408.36   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
TMED8
Tdark
Novelty:  1.41977071
p_int:  0.995148044
p_ni:  0.004851941
p_wrong:  1.6e-8
Score:  0.214
Data Source:  BioPlex,STRINGDB
COPG1
Tbio
Novelty:  0.01331193
p_int:  0.979904306
p_ni:  0.020095694
Score:  0.204
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.965926047
p_ni:  0.034073953
Data Source:  BioPlex
ARL10
Tdark
Family:  Enzyme
Novelty:  1.16329406
p_int:  0.964229321
p_ni:  0.035769398
p_wrong:  0.000001281
Data Source:  BioPlex
GRAMD1A
Tbio
Novelty:  0.15461113
p_int:  0.942424343
p_ni:  0.057575657
Data Source:  BioPlex
BAG1
Tbio
Novelty:  0.00285515
p_int:  0.937474536
p_ni:  0.052345053
p_wrong:  0.010180411
Score:  0.165
Data Source:  BioPlex,STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
p_int:  0.936347578
p_ni:  0.02504209
p_wrong:  0.038610332
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.931863669
p_ni:  0.028762571
p_wrong:  0.03937376
Data Source:  BioPlex
COPG2
Tbio
Novelty:  0.06126837
p_int:  0.904591611
p_ni:  0.095408389
Data Source:  BioPlex
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.887739337
p_ni:  0.000066642
p_wrong:  0.112194021
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Activation of G protein gated Potassium channels (R-HSA-1296041)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
G protein gated Potassium channels
Reactome
GABA B receptor activation
Reactome
GABA receptor activation
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
G protein gated Potassium channels
GABA B receptor activation
GABA receptor activation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
3
3
90.5
mean platelet volume
3
1
3
84.7
electrocardiography
1
1
3
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
3
90.5
mean platelet volume
3
84.7
electrocardiography
3
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1194504
16513
Rat
RGD:61822
29718
Horse
potassium voltage-gated channel subfamily J member 10
VGNC:19284
100058121
Cow
potassium voltage-gated channel subfamily J member 10
VGNC:30454
533343
Opossum
potassium voltage-gated channel subfamily J member 10
100023256
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
potassium voltage-gated channel subfamily J member 10
Cow
potassium voltage-gated channel subfamily J member 10
Opossum
potassium voltage-gated channel subfamily J member 10
Publication Statistics
PubMed Score 408.36
PubMed score by year
PubTator Score 152.57
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title