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Tbio
JAG1
Protein jagged-1

Protein Summary
Description
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254958
  • ENSP00000254958
  • ENSG00000101384

Symbol
  • JAGL1
  • AGS
  • AHD
  • AWS
  • HJ1
  • AGS1
  • DCHE
  • CD339
  • JAGL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
1
biological process
0.97
gene perturbation
0.95
transcription factor perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.04   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 656   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1005.04   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 656   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
12
98.1
bone density
3
3
4
97.7
monocyte count
2
2
2
64.8
hematocrit
1
1
1
64.5
red blood cell density measurement
1
1
1
60.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
98.1
bone density
4
97.7
monocyte count
2
64.8
hematocrit
1
64.5
red blood cell density measurement
1
60.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
jagged 1
VGNC:6177
748073
Macaque
jagged 1
718580
Mouse
MGI:1095416
16449
Rat
RGD:2937
29146
Dog
jagged 1
VGNC:42172
485769
Species
Name
OMA
EggNOG
Inparanoid
Chimp
jagged 1
Macaque
jagged 1
Mouse
Rat
Dog
jagged 1
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78504-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (57)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Constitutive Signaling by NOTCH1 HD Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 HD Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Protein-Protein Interactions (235)
1 – 10 of 235
ADAM17
Tchem
Family: Enzyme
Novelty: 0.00121971
Score: 0.977
Data Source: STRINGDB
NEURL1
Tbio
Family: Enzyme
Novelty: 0.05370537
Score: 0.977
Data Source: STRINGDB
MIB1
Tbio
Family: Enzyme
Novelty: 0.03288048
Score: 0.975
Data Source: STRINGDB
NOTCH2
Tchem
Novelty: 0.00195617
Score: 0.969
Data Source: Reactome,STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.969
Data Source: Reactome,STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.969
Data Source: Reactome,STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.968
Data Source: STRINGDB
ADAM10
Tchem
Family: Enzyme
Novelty: 0.00160129
Score: 0.966
Data Source: Reactome,STRINGDB
NEURL1B
Tdark
Family: Enzyme
Novelty: 0.16762429
Score: 0.96
Data Source: STRINGDB
MFAP5
Tbio
Novelty: 0.01839035
Score: 0.956
Data Source: STRINGDB
Publication Statistics
PubMed Score  1005.04

PubMed score by year
PubTator Score  659.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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