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Tbio
CX3CL1
Fractalkine

Protein Summary
Description
Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000006053
  • ENSP00000006053
  • ENSG00000006210

Symbol
  • FKN
  • NTT
  • SCYD1
  • NTN
  • NTT
  • CXC3
  • CXC3C
  • SCYD1
  • ABCD-3
  • C3Xkine
  • fractalkine
  • neurotactin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
biological term
0.97
transcription factor perturbation
0.94
PubMedID
0.91
disease
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.21   (req: < 5)
Gene RIFs: 232   (req: <= 3)
Antibodies: 699   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.21   (req: >= 5)
Gene RIFs: 232   (req: > 3)
Antibodies: 699   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
1
1
80.1
blood protein measurement
1
1
1
79.5
eosinophil count
1
1
1
24.6
eosinophil percentage of leukocytes
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
CX3CL1 measurement
1
80.1
blood protein measurement
1
79.5
eosinophil count
1
24.6
eosinophil percentage of leukocytes
1
8.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X3-C motif chemokine ligand 1
VGNC:7411
454115
Macaque
C-X3-C motif chemokine ligand 1
574225
Mouse
MGI:1097153
20312
Rat
RGD:620458
89808
Dog
C-X3-C motif chemokine ligand 1
VGNC:39745
487265
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X3-C motif chemokine ligand 1
Macaque
C-X3-C motif chemokine ligand 1
Mouse
Rat
Dog
C-X3-C motif chemokine ligand 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78423-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (215)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (82)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Mutant Phenotype (IMP)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (337)
1 – 10 of 337
CX3CR1
Tchem
Family: GPCR
Novelty: 0.00114874
Score: 0.997
Data Source: Reactome,STRINGDB
CCL5
Tchem
Novelty: 0.00032607
Score: 0.974
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.97
Data Source: STRINGDB
CCR2
Tchem
Family: GPCR
Novelty: 0.0006525
Score: 0.97
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.969
Data Source: STRINGDB
CXCL8
Tchem
Novelty: 0.00005958
Score: 0.967
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.966
Data Source: STRINGDB
CCL4
Tbio
Novelty: 0.00069278
Score: 0.966
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.964
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  910.21

PubMed score by year
PubTator Score  396.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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