Tbio IRX1 Iroquois-class homeodomain protein IRX-1

Protein Summary

Description

This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• P78414
• Q7Z2F8
• Q8N312

Gene Name

• IRX1

Ensembl ID

• ENST00000302006
• ENSP00000305244
• ENSG00000170549

Symbol

• IRXA1
• IRX-5
• IRXA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
PubMedID	0.67
cell line	0.66
transcription factor	0.55
disease	0.54

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Iroquois-class Homeodomain Protein Irx-1

Protein / Nucleic Acid Binding / Iroquois-class Homeodomain Protein Irx-1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Iroquois-class Homeodomain Protein Irx-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.14   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.14   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0