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Tbio
IRX1
Iroquois-class homeodomain protein IRX-1

Protein Summary
Description
This gene encodes a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302006
  • ENSP00000305244
  • ENSG00000170549

Symbol
  • IRXA1
  • IRX-5
  • IRXA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.67
cell line
0.66
transcription factor
0.55
disease
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.64   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.64   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
1
1
22
glomerular filtration rate
2
1
1
5.8
13.5
red blood cell distribution width
2
1
2
7.9
diastolic blood pressure
1
1
1
6.8
1
1
0
2.3
5.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
22
glomerular filtration rate
1
5.8
13.5
red blood cell distribution width
2
7.9
diastolic blood pressure
1
6.8
0
2.3
5.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
iroquois homeobox 1
VGNC:4050
750962
Macaque
iroquois homeobox 1
693825
Mouse
MGI:1197515
16371
Rat
RGD:1309060
306659
Horse
iroquois homeobox 1 [Source:HGNC Symbol;Acc:HGNC:14358]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
iroquois homeobox 1
Macaque
iroquois homeobox 1
Mouse
Rat
Horse
iroquois homeobox 1 [Source:HGNC Symbol;Acc:HGNC:14358]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P78414-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (81)
1 – 10 of 81
KCND2
Tclin
Family: IC
Novelty: 0.00297203
Score: 0.927
Data Source: STRINGDB
DLX2
Tbio
Family: TF
Novelty: 0.00609908
Score: 0.789
Data Source: STRINGDB
DLX1
Tbio
Family: TF
Novelty: 0.01359424
Score: 0.786
Data Source: STRINGDB
SMYD1
Tbio
Family: Epigenetic
Novelty: 0.03781475
Score: 0.719
Data Source: STRINGDB
FOXP1
Tbio
Family: TF
Novelty: 0.00337994
Score: 0.71
Data Source: STRINGDB
AKAP11
Tbio
Family: Enzyme
Novelty: 0.0685826
Score: 0.64
Data Source: STRINGDB
BUB3
Tbio
Novelty: 0.00714143
Score: 0.623
Data Source: STRINGDB
KCNE4
Tbio
Family: IC
Novelty: 0.04524673
Score: 0.623
Data Source: STRINGDB
RUNX1T1
Tbio
Novelty: 0.0039633
Score: 0.593
Data Source: STRINGDB
GPD1L
Tbio
Family: Enzyme
Novelty: 0.0169606
Score: 0.579
Data Source: STRINGDB
Publication Statistics
PubMed Score  57.64

PubMed score by year
PubTator Score  17.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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