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Tbio
IRX5
Iroquois-class homeodomain protein IRX-5

Protein Summary
Description
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. This gene encodes a member of the iroquois homeobox gene family, which are involved in several embryonic developmental processes. Knockout mice lacking this gene show that it is required for retinal cone bipolar cell differentiation, and that it negatively regulates potassium channel gene expression in the heart to ensure coordinated cardiac repolarization. Alternatively spliced transcript variants encoding different isoform ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320990
  • ENSP00000316250
  • ENSG00000176842
  • ENST00000394636
  • ENSP00000378132

Symbol
  • IRX2A
  • IRXB2
  • HMMS
  • IRXB2
  • IRX-2a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
transcription factor binding site profile
0.83
protein domain
0.73
biological process
0.64
tissue sample
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.02   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.02   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
iroquois homeobox 5
697968
Mouse
MGI:1859086
54352
Rat
RGD:1565518
498918
Dog
iroquois homeobox 5
VGNC:52139
487276
Cow
iroquois homeobox 5
VGNC:30289
532896
Species
Name
OMA
EggNOG
Inparanoid
Macaque
iroquois homeobox 5
Mouse
Rat
Dog
iroquois homeobox 5
Cow
iroquois homeobox 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P78411-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (48)
1 – 10 of 48
TIMM10
Tbio
Family: Enzyme
Novelty: 0.02727463
p_int: 0.832073151
p_ni: 0.000001489
p_wrong: 0.167925359
Data Source: BioPlex
KCND2
Tclin
Family: IC
Novelty: 0.00297203
Score: 0.941
Data Source: STRINGDB
SMYD1
Tbio
Family: Epigenetic
Novelty: 0.03781475
Score: 0.751
Data Source: STRINGDB
VSX1
Tbio
Family: TF
Novelty: 0.01213324
Score: 0.674
Data Source: STRINGDB
GPD1L
Tbio
Family: Enzyme
Novelty: 0.0169606
Score: 0.672
Data Source: STRINGDB
KCNE4
Tbio
Family: IC
Novelty: 0.04524673
Score: 0.644
Data Source: STRINGDB
FTO
Tbio
Family: Enzyme
Novelty: 0.00053473
Score: 0.595
Data Source: STRINGDB
RUNX1T1
Tbio
Novelty: 0.0039633
Score: 0.592
Data Source: STRINGDB
KCNIP2
Tbio
Family: IC
Novelty: 0.01123517
Score: 0.548
Data Source: STRINGDB
BHLHE23
Tdark
Family: TF
Novelty: 0.02417856
Score: 0.547
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.02

PubMed score by year
PubTator Score  12.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer