You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BTN3A2
Butyrophilin subfamily 3 member A2

Protein Summary
Description
Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells. This gene encodes a member of the immunoglobulin superfamily, which resides in the juxta-telomeric region of the major histocompatability class 1 locus and is clustered with the other family members on chromosome 6. The encoded protein may be involved in the adaptive immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356386
  • ENSP00000348751
  • ENSG00000186470
  • ENST00000377708
  • ENSP00000366937
  • ENST00000396934
  • ENSP00000380140
  • ENST00000396948
  • ENSP00000380152
  • ENST00000508906
  • ENSP00000442687
  • ENST00000527422
  • ENSP00000432138

Symbol
  • BT3.2
  • BTF3
  • BTF4
  • BTF4
  • BT3.2
  • CD277
  • BTN3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.74
histone modification site profile
0.72
PubMedID
0.62
tissue sample
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0