Tbio RAE1 mRNA export factor

Protein Summary

Description

Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78406
• A8K882
• O15306
• Q3SYL7
• Q5TCH8
• Q6V708
• Q9H100
• Q9NQM6

Gene Name

• RAE1

Ensembl ID

• ENST00000371242
• ENSP00000360286
• ENSG00000101146
• ENST00000395840
• ENSP00000379181
• ENST00000395841
• ENSP00000379182

Symbol

• MRNP41
• Gle2
• MIG14
• MRNP41
• Mnrp41
• dJ481F12.3
• dJ800J21.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
cellular component	0.82
transcription factor perturbation	0.8
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Export Factor

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Export Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.43   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.43   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0