Tbio RAE1 mRNA export factor

Protein Summary

Description

Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78406
• A8K882
• O15306
• Q3SYL7
• Q5TCH8
• Q6V708
• Q9H100
• Q9NQM6

Gene Name

• RAE1

Ensembl ID

• ENST00000371242
• ENSP00000360286
• ENSG00000101146
• ENST00000395840
• ENSP00000379181
• ENST00000395841
• ENSP00000379182

Symbol

• MRNP41
• Gle2
• MIG14
• MRNP41
• Mnrp41
• dJ481F12.3
• dJ800J21.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
cellular component	0.82
transcription factor perturbation	0.8
kinase perturbation	0.76

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Export Factor

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Export Factor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.89   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.89   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (262)

Explore Interacting Targets

1 – 10 of 262

• See Interactions on String-DB

AGGF1

Tbio

Novelty:  0.02757407

p_int:  0.999978539

p_ni:  0.000021461

Score:  0.196

Data Source:  BioPlex,STRINGDB

BUB1

Tchem

Family:  Kinase

Novelty:  0.00327514

p_int:  0.991893563

p_ni:  0.008106437

Score:  0.841

Data Source:  BioPlex,STRINGDB

GYG2

Tbio

Family:  Enzyme

Novelty:  0.01520991

p_int:  0.990452976

p_ni:  0.009547024

Score:  0.163

Data Source:  BioPlex,STRINGDB

BUB1B

Tbio

Family:  Kinase

Novelty:  0.00239073

p_int:  0.982956642

p_ni:  0.017043358

Score:  0.954

Data Source:  BioPlex,STRINGDB

ARHGAP22

Tbio

Family:  Enzyme

Novelty:  0.13037853

p_int:  0.978976797

p_ni:  0.021023203

Data Source:  BioPlex

PRIM1

Tbio

Family:  Enzyme

Novelty:  0.0530384

p_int:  0.961365129

p_ni:  0.038634871

Score:  0.661

Data Source:  BioPlex,STRINGDB

NUP98

Tbio

Family:  Enzyme

Novelty:  0.00401452

p_int:  0.935503829

p_ni:  0.064496171

Score:  0.997

Data Source:  BioPlex,STRINGDB

HGFAC

Tchem

Family:  Enzyme

Novelty:  0.00620243

p_int:  0.93147339

p_ni:  0.06852661

Data Source:  BioPlex

LGALS3BP

Tbio

Novelty:  0.0025302

p_int:  0.890906706

p_ni:  0.109093294

Score:  0.257

Data Source:  BioPlex,STRINGDB

FBXW7

Tbio

Novelty:  0.00180856

p_int:  0.799957455

p_ni:  0.200042545

Score:  0.438

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (70)

Reactome (68)

KEGG (2)

Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cellular response to heat stress	100 targets	R-HSA-3371556
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897

Name	Explore in Pharos	Explore in Source
Antiviral mechanism by IFN-stimulated genes	82 targets	R-HSA-1169410
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cellular response to heat stress	100 targets	R-HSA-3371556
Cellular responses to external stimuli	487 targets	R-HSA-8953897

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (16)

Functions (3)

Components (6)

Processes (7)

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1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from Direct Assay (IDA)	GO_Central
ubiquitin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
microtubule binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (25)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 25

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	6	8	13		98.4
mean reticulocyte volume	EFO_0010701	1	4	4		98.3
mean corpuscular volume	EFO_0004526	4	4	5		98.1
reticulocyte measurement	EFO_0010700	3	6	8		97.8
mean platelet volume	EFO_0004584	3	3	4		91.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 25

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	13		98.4
mean reticulocyte volume	EFO_0010701	4		98.3
mean corpuscular volume	EFO_0004526	5		98.1
reticulocyte measurement	EFO_0010700	8		97.8
mean platelet volume	EFO_0004584	4		91.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Mitosis
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
appendicular lean mass
colorectal cancer
electrocardiography
erythrocyte count
erythrocyte measurement
HbA1c measurement
hematocrit
hemoglobin measurement
high density lipoprotein cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
homeostasis/metabolism phenotype
mortality/aging
neoplasm

IDG Resources

No IDG generated resources found

Orthologs (17)

1 – 5 of 17

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribonucleic acid export 1	VGNC:6253	469982
Macaque	ribonucleic acid export 1 [Source:HGNC Symbol;Acc:HGNC:9828]
Mouse	ribonucleic acid export 1	MGI:1913929	66679
Rat	ribonucleic acid export 1	RGD:1311540	362281
Dog	ribonucleic acid export 1	VGNC:45324	485942

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribonucleic acid export 1
Macaque	ribonucleic acid export 1 [Source:HGNC Symbol;Acc:HGNC:9828]
Mouse	ribonucleic acid export 1
Rat	ribonucleic acid export 1
Dog	ribonucleic acid export 1

Publication Statistics

PubMed Score 58.89

PubMed score by year

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PubTator Score 40.26

PubTator score by year

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Related Publications

Text Mined References (33)

GeneRif Annotations (17)

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PMID	Year	Title