Protein Summary
Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000371242
- ENSP00000360286
- ENSG00000101146
- ENST00000395840
- ENSP00000379181
- ENST00000395841
- ENSP00000379182
- MRNP41
- Gle2
- MIG14
- MRNP41
- Mnrp41
- dJ481F12.3
- dJ800J21.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
cellular component | 0.82 | ||
transcription factor perturbation | 0.8 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.89 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 203 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.89 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 203 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (262)
AGGF1
Novelty: 0.02757407
p_int: 0.999978539
p_ni: 0.000021461
Score: 0.196
Data Source: BioPlex,STRINGDB
BUB1
Family: Kinase
Novelty: 0.00327514
p_int: 0.991893563
p_ni: 0.008106437
Score: 0.841
Data Source: BioPlex,STRINGDB
GYG2
Family: Enzyme
Novelty: 0.01520991
p_int: 0.990452976
p_ni: 0.009547024
Score: 0.163
Data Source: BioPlex,STRINGDB
BUB1B
Family: Kinase
Novelty: 0.00239073
p_int: 0.982956642
p_ni: 0.017043358
Score: 0.954
Data Source: BioPlex,STRINGDB
ARHGAP22
Family: Enzyme
Novelty: 0.13037853
p_int: 0.978976797
p_ni: 0.021023203
Data Source: BioPlex
PRIM1
Family: Enzyme
Novelty: 0.0530384
p_int: 0.961365129
p_ni: 0.038634871
Score: 0.661
Data Source: BioPlex,STRINGDB
NUP98
Family: Enzyme
Novelty: 0.00401452
p_int: 0.935503829
p_ni: 0.064496171
Score: 0.997
Data Source: BioPlex,STRINGDB
HGFAC
Family: Enzyme
Novelty: 0.00620243
p_int: 0.93147339
p_ni: 0.06852661
Data Source: BioPlex
LGALS3BP
Novelty: 0.0025302
p_int: 0.890906706
p_ni: 0.109093294
Score: 0.257
Data Source: BioPlex,STRINGDB
FBXW7
Novelty: 0.00180856
p_int: 0.799957455
p_ni: 0.200042545
Score: 0.438
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (70)
Reactome (68)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Antiviral mechanism by IFN-stimulated genes | ||||
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (6)
Processes (7)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
reticulocyte count | 6 | 8 | 13 | 98.4 | |||||
mean reticulocyte volume | 1 | 4 | 4 | 98.3 | |||||
mean corpuscular volume | 4 | 4 | 5 | 98.1 | |||||
reticulocyte measurement | 3 | 6 | 8 | 97.8 | |||||
mean platelet volume | 3 | 3 | 4 | 91.7 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
reticulocyte count | 13 | 98.4 | |||||
mean reticulocyte volume | 4 | 98.3 | |||||
mean corpuscular volume | 5 | 98.1 | |||||
reticulocyte measurement | 8 | 97.8 | |||||
mean platelet volume | 4 | 91.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (17)
1 – 5 of 17
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ribonucleic acid export 1 | VGNC:6253 | 469982 | |||||
Macaque | ribonucleic acid export 1 [Source:HGNC Symbol;Acc:HGNC:9828] | |||||||
Mouse | MGI:1913929 | 66679 | ||||||
Rat | RGD:1311540 | 362281 | ||||||
Dog | ribonucleic acid export 1 | VGNC:45324 | 485942 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ribonucleic acid export 1 | |||||
Macaque | ribonucleic acid export 1 [Source:HGNC Symbol;Acc:HGNC:9828] | |||||
Mouse | ||||||
Rat | ||||||
Dog | ribonucleic acid export 1 | |||||
Publication Statistics
PubMed Score 58.89
PubMed score by year
PubTator Score 40.26
PubTator score by year
Related Publications
Text Mined References (33)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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