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Tbio
CCNA1
Cyclin-A1

Protein Summary
Description
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255465
  • ENSP00000255465
  • ENSG00000133101
  • ENST00000440264
  • ENSP00000400666
  • ENST00000625767
  • ENSP00000486017
  • ENST00000630422
  • ENSP00000486482

Symbol
  • CT146
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
gene perturbation
0.85
hub protein
0.75
tissue sample
0.74
histone modification site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.01   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.01   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
5.7
Pathways (73)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

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Items per page:
1 – 5 of 55
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
CDK-mediated phosphorylation and removal of Cdc6
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
CDK-mediated phosphorylation and removal of Cdc6
Protein-Protein Interactions (341)
1 – 10 of 341
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.99999988
p_wrong: 1.2e-7
Score: 0.924
Data Source: BioPlex,STRINGDB
CDKN1A
Tbio
Family: Enzyme
Novelty: 0.00033009
Score: 0.999
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.995
Data Source: Reactome,STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
Score: 0.994
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.993
Data Source: STRINGDB
MCM6
Tbio
Novelty: 0.00675724
Score: 0.993
Data Source: STRINGDB
MCM4
Tbio
Novelty: 0.00604311
Score: 0.992
Data Source: STRINGDB
CDC6
Tbio
Novelty: 0.00219371
Score: 0.985
Data Source: STRINGDB
CDC25A
Tchem
Family: Enzyme
Novelty: 0.00250149
Score: 0.982
Data Source: STRINGDB
UBE2C
Tbio
Novelty: 0.00731185
Score: 0.979
Data Source: STRINGDB
Publication Statistics
PubMed Score  143.01

PubMed score by year
PubTator Score  91.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer