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Tbio
PRAME
Melanoma antigen preferentially expressed in tumors

Protein Summary
Description
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398741
  • ENSP00000381726
  • ENSG00000185686
  • ENST00000398743
  • ENSP00000381728
  • ENST00000402697
  • ENSP00000385198
  • ENST00000405655
  • ENSP00000384343
  • ENST00000539862
  • ENSP00000445097
  • ENSG00000275013
  • ENST00000543184
  • ENSP00000445675
  • ENST00000617728
  • ENSP00000484066
  • ENST00000626503
  • ENSP00000486485
  • ENST00000628830
  • ENSP00000486330

Symbol
  • MAPE
  • OIP4
  • MAPE
  • OIP4
  • CT130
  • OIP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
biological process
0.71
tissue sample
0.7
biological term
0.67
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.29   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.29   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (85)
1 – 10 of 85
IFT81
Tbio
Novelty: 0.00856499
p_int: 0.99985574
p_ni: 0.000144259
p_wrong: 2e-9
Data Source: BioPlex
LAGE3
Tdark
Novelty: 0.03704357
p_int: 0.999815525
p_ni: 0.000184092
p_wrong: 3.82e-7
Score: 0.419
Data Source: BioPlex,STRINGDB
MLST8
Tbio
Novelty: 0.00212271
p_int: 0.997732474
p_ni: 0.002267372
p_wrong: 1.54e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
AZIN2
Tbio
Family: Enzyme
Novelty: 0.00985172
p_int: 0.994400216
p_ni: 0.005599767
p_wrong: 1.7e-8
Score: 0.161
Data Source: BioPlex,STRINGDB
QTRT1
Tbio
Family: Enzyme
Novelty: 0.06198347
p_int: 0.986839625
p_ni: 0.012360019
p_wrong: 0.000800355
Score: 0.19
Data Source: BioPlex,STRINGDB
EEF1D
Tbio
Novelty: 0.0317015
p_int: 0.985341224
p_ni: 0.014658776
Data Source: BioPlex
SIRT6
Tchem
Family: Epigenetic
Novelty: 0.00185315
p_int: 0.979038401
p_ni: 0.020717756
p_wrong: 0.000243843
Data Source: BioPlex
ZNF562
Tdark
Family: TF
p_int: 0.976861728
p_ni: 0.022481821
p_wrong: 0.000656451
Score: 0.161
Data Source: BioPlex,STRINGDB
GATD1
Tdark
Family: Enzyme
Novelty: 1
p_int: 0.975326918
p_ni: 0.02227025
p_wrong: 0.002402832
Data Source: BioPlex
NPY2R
Tchem
Family: GPCR
Novelty: 0.01163073
p_int: 0.975209563
p_ni: 0.024269417
p_wrong: 0.00052102
Data Source: BioPlex
Publication Statistics
PubMed Score  252.29

PubMed score by year
PubTator Score  145.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer