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Tbio
KRT83
Keratin, type II cuticular Hb3

Protein Summary
Description
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293670
  • ENSP00000293670
  • ENSG00000170523

Symbol
  • KRTHB3
  • HB3
  • Hb-3
  • EKVP5
  • MNLIX
  • KRTHB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.8
gene perturbation
0.62
protein domain
0.58
tissue
0.58
cell line
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.45   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.45   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (70)
1 – 10 of 70
KRT25
Tbio
Novelty: 0.24351194
Score: 0.934
Data Source: STRINGDB
KRT34
Tbio
Novelty: 0.1177908
Score: 0.929
Data Source: STRINGDB
KRT38
Tdark
Novelty: 0.35478736
Score: 0.929
Data Source: STRINGDB
KRT24
Tbio
Novelty: 0.05223694
Score: 0.927
Data Source: STRINGDB
KRT35
Tbio
Novelty: 0.02043185
Score: 0.927
Data Source: STRINGDB
KRT32
Tdark
Novelty: 13
Score: 0.927
Data Source: STRINGDB
KRT37
Tdark
Novelty: 0.03979606
Score: 0.924
Data Source: STRINGDB
KRT14
Tbio
Novelty: 0.0012542
Score: 0.924
Data Source: STRINGDB
KRT16
Tbio
Novelty: 0.00602741
Score: 0.923
Data Source: STRINGDB
KRT15
Tbio
Novelty: 0.00514754
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.45

PubMed score by year
PubTator Score  45.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer