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Tbio
SLC35A1
CMP-sialic acid transporter

Protein Summary
Description
Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369552
  • ENSP00000358565
  • ENSG00000164414
  • ENST00000369556
  • ENSP00000358569

Symbol
  • CST
  • hCST
  • CDG2F
  • CMPST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.88
molecular function
0.88
pathway
0.86
histone modification site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.4   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.4   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
ICK
Tchem
Family:  Kinase
Novelty:  0.00810476
p_int:  0.983232285
p_ni:  0.014527947
p_wrong:  0.002239768
Score:  0.345
Data Source:  BioPlex,STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
p_int:  0.804339891
p_ni:  0.195659774
p_wrong:  3.35e-7
Score:  0.359
Data Source:  BioPlex,STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.927
Data Source:  STRINGDB
SLC35C1
Tbio
Family:  Transporter
Novelty:  0.05958023
Score:  0.815
Data Source:  STRINGDB
GNE
Tbio
Family:  Enzyme
Novelty:  0.00285751
Score:  0.782
Data Source:  STRINGDB
ST3GAL4
Tbio
Family:  Enzyme
Novelty:  0.00419433
Score:  0.772
Data Source:  STRINGDB
PLPP4
Tbio
Family:  Enzyme
Novelty:  0.22418589
Score:  0.751
Data Source:  STRINGDB
SLC35B3
Tdark
Family:  Transporter
Novelty:  0.10252233
Score:  0.736
Data Source:  STRINGDB
SLC35D1
Tbio
Family:  Transporter
Novelty:  0.08762897
Score:  0.691
Data Source:  STRINGDB
COG3
Tbio
Novelty:  0.02746711
Score:  0.673
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)
Disease
Disorders of transmembrane transporters
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
1
2
75.7
mathematical ability
2
2
2
69.6
self reported educational attainment
1
1
1
63.4
household income
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
75.7
mathematical ability
2
69.6
self reported educational attainment
1
63.4
household income
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member A1
VGNC:7926
462874
Mouse
MGI:1345622
24060
Rat
RGD:1311359
313139
Dog
solute carrier family 35 member A1
VGNC:46360
403594
Horse
solute carrier family 35 member A1
VGNC:23161
100070654
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 35 member A1
Mouse
Rat
Dog
solute carrier family 35 member A1
Horse
solute carrier family 35 member A1
Publication Statistics
PubMed Score 50.40
PubMed score by year
PubTator Score 13.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title