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Tbio
OLR1
Oxidized low-density lipoprotein receptor 1

Protein Summary
Description
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for ad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309539
  • ENSP00000309124
  • ENSG00000173391
  • ENST00000432556
  • ENSP00000405116
  • ENST00000545927
  • ENSP00000439251

Symbol
  • CLEC8A
  • LOX1
  • LOX1
  • LOXIN
  • SLOX1
  • CLEC8A
  • SCARE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
biological term
0.96
disease
0.75
tissue
0.64
cellular component
0.63


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.15   (req: < 5)
Gene RIFs: 227   (req: <= 3)
Antibodies: 618   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 964.15   (req: >= 5)
Gene RIFs: 227   (req: > 3)
Antibodies: 618   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxidized low density lipoprotein receptor 1
VGNC:8479
473362
Macaque
oxidized low density lipoprotein receptor 1
717596
Mouse
MGI:1261434
108078
Rat
RGD:620515
140914
Dog
oxidized low density lipoprotein receptor 1
VGNC:44120
486694
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxidized low density lipoprotein receptor 1
Macaque
oxidized low density lipoprotein receptor 1
Mouse
Rat
Dog
oxidized low density lipoprotein receptor 1
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78380-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (180)
1 – 10 of 180
F5
Tbio
Novelty: 0.00161772
p_int: 0.999992129
p_ni: 0.00000787
p_wrong: 1e-9
Score: 0.685
Data Source: BioPlex,STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.952
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.948
Data Source: STRINGDB
CYBA
Tbio
Novelty: 0.00177762
Score: 0.938
Data Source: STRINGDB
CD36
Tbio
Novelty: 0.00140825
Score: 0.936
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.929
Data Source: STRINGDB
HSPA4
Tbio
Novelty: 0.00009122
Score: 0.927
Data Source: STRINGDB
ITGAM
Tbio
Novelty: 0.00017521
Score: 0.925
Data Source: STRINGDB
CLEC5A
Tbio
Novelty: 0.01710591
Score: 0.923
Data Source: STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  964.15

PubMed score by year
PubTator Score  538.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer