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Tbio
CCT2
T-complex protein 1 subunit beta

Protein Classes
Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299300
  • ENSP00000299300
  • ENSG00000166226
  • ENST00000543146
  • ENSP00000445471

Symbol
  • 99D8.1
  • CCTB
  • CCTB
  • 99D8.1
  • PRO1633
  • CCT-beta
  • HEL-S-100n
  • TCP-1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
hub protein
1
interacting protein
1
kinase perturbation
1
disease perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.13   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.13   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (16)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Protein-Protein Interactions (681)
1 – 10 of 681
WDR24
Tdark
Novelty: 1.44736842
p_int: 0.999999873
p_ni: 1.27e-7
Data Source: BioPlex
KATNB1
Tbio
Novelty: 0.07705479
p_int: 0.999999546
p_ni: 4.54e-7
Data Source: BioPlex
WDR70
Tdark
Novelty: 1.2244898
p_int: 0.999999535
p_ni: 4.65e-7
Data Source: BioPlex
TUBD1
Tbio
Novelty: 0.05057515
p_int: 0.999999283
p_ni: 3.02e-7
p_wrong: 4.15e-7
Score: 0.228
Data Source: BioPlex,STRINGDB
DCAF12
Tbio
Novelty: 0.09567198
p_int: 0.999999109
p_ni: 8.35e-7
p_wrong: 5.5e-8
Data Source: BioPlex
DCAF13
Tbio
Novelty: 0.00828554
p_int: 0.999997282
p_ni: 0.000002707
p_wrong: 1.1e-8
Score: 0.289
Data Source: BioPlex,STRINGDB
WDR25
Tdark
Novelty: 0.69230769
p_int: 0.999996329
p_ni: 0.000003357
p_wrong: 3.14e-7
Data Source: BioPlex
RFWD3
Tbio
Family: Enzyme
Novelty: 0.15397776
p_int: 0.999992686
p_ni: 0.000007314
Data Source: BioPlex
KATNAL1
Tbio
Family: Enzyme
Novelty: 0.12012012
p_int: 0.99998947
p_ni: 5.42e-7
p_wrong: 0.000009988
Data Source: BioPlex
NEDD1
Tbio
Novelty: 0.03704684
p_int: 0.99998601
p_ni: 0.00001399
Score: 0.267
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  32.13

PubMed score by year
PubTator Score  25.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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