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Tchem
CSNK1G2
Casein kinase I isoform gamma-2

Protein Summary
Description
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255641
  • ENSP00000255641
  • ENSG00000133275

Symbol
  • CK1G2
  • CK1g2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.87
gene perturbation
0.76
protein domain
0.73
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
75.8
red blood cell distribution width
2
1
2
73.5
C-reactive protein measurement
1
1
1
65.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
75.8
red blood cell distribution width
2
73.5
C-reactive protein measurement
1
65.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (R-HSA-4641262)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Metabolism
Metabolism of lipids
Signal Transduction
Signaling by WNT
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (62)
1 – 10 of 62
CSNK1G3
Tbio
Family: Kinase
Novelty: 0.07584067
p_int: 1
Score: 0.535
Data Source: BioPlex,STRINGDB
CSNK1G1
Tchem
Family: Kinase
Novelty: 0.10919141
p_int: 0.999999998
p_ni: 2e-9
Score: 0.857
Data Source: BioPlex,STRINGDB
GINS2
Tbio
Novelty: 0.0078966
p_int: 0.999890689
p_ni: 0.000109032
p_wrong: 2.79e-7
Score: 0.758
Data Source: BioPlex,STRINGDB
COL4A3BP
Tbio
Novelty: 0.00357203
p_int: 0.99834726
p_ni: 0.00165274
p_wrong: 1e-9
Score: 0.584
Data Source: BioPlex,Reactome,STRINGDB
GINS4
Tbio
Novelty: 0.0316194
p_int: 0.997446164
p_ni: 0.002553836
Score: 0.666
Data Source: BioPlex,STRINGDB
DCAF16
Tdark
Novelty: 0.35666992
p_int: 0.994123615
p_ni: 0.004074583
p_wrong: 0.001801802
Score: 0.179
Data Source: BioPlex,STRINGDB
GINS3
Tbio
Novelty: 0.02892519
p_int: 0.993762599
p_ni: 0.006237401
Score: 0.819
Data Source: BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty: 1.8251367
p_int: 0.951031596
p_ni: 0.048968378
p_wrong: 2.6e-8
Data Source: BioPlex
GINS1
Tbio
Novelty: 0.08722396
p_int: 0.9481938
p_ni: 0.051806198
p_wrong: 2e-9
Score: 0.722
Data Source: BioPlex,STRINGDB
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.854095049
p_ni: 0.145904951
Score: 0.213
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.13

PubMed score by year
PubTator Score  5.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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