Tchem CSNK1G2 Casein kinase I isoform gamma-2

Protein Summary

Description

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Uniprot Accession IDs

• P78368
• B5BU42
• O00704
• Q8WUB1
• CKI-gamma 2

Gene Name

• CSNK1G2

Ensembl ID

• ENST00000255641
• ENSP00000255641
• ENSG00000133275

Symbol

• CK1G2
• CK1g2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
disease perturbation	0.87
gene perturbation	0.76
protein domain	0.73
transcription factor binding site profile	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Casein Kinase I Isoform Gamma-2

DTO Classes

Protein / Kinase / Protein Kinase / Ck1 Group / Ck1 Family / Casein Kinase I Isoform Gamma-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 414   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0