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Tbio
NKX3-2
Homeobox protein Nkx-3.2

Protein Summary
Description
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382438
  • ENSP00000371875
  • ENSG00000109705

Symbol
  • BAPX1
  • NKX3B
  • SMMD
  • BAPX1
  • NKX3B
  • NKX3.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
molecular function
0.76
small molecule perturbation
0.63
PubMedID
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.02   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.02   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
HIVEP3
Tbio
Family:  TF
Novelty:  0.02321588
Score:  0.934
Data Source:  STRINGDB
MSX2
Tbio
Family:  TF
Novelty:  0.00273602
Score:  0.924
Data Source:  STRINGDB
DLX5
Tbio
Family:  TF
Novelty:  0.00418303
Score:  0.922
Data Source:  STRINGDB
DLX6
Tbio
Family:  TF
Novelty:  0.01455012
Score:  0.92
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.909
Data Source:  STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.902
Data Source:  STRINGDB
WWP1
Tbio
Family:  Enzyme
Novelty:  0.01407874
Score:  0.902
Data Source:  STRINGDB
CBFB
Tchem
Family:  TF
Novelty:  0.04825679
Score:  0.9
Data Source:  STRINGDB
SOX9
Tbio
Family:  TF
Novelty:  0.00047439
Score:  0.848
Data Source:  STRINGDB
PAX9
Tbio
Family:  TF
Novelty:  0.00581813
Score:  0.777
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of RUNX2 expression and activity
Reactome
Transcriptional regulation by RUNX2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of RUNX2 expression and activity
Transcriptional regulation by RUNX2
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip geometry
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip geometry
1
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108015
12020
Dog
NK3 homeobox 2
VGNC:43836
488822
Cow
NK3 homeobox 2
VGNC:32106
616907
Opossum
NK3 homeobox 2
100016352
Xenopus
NK3 homeobox 2
XB-GENE-876834
100497965
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
NK3 homeobox 2
Cow
NK3 homeobox 2
Opossum
NK3 homeobox 2
Xenopus
NK3 homeobox 2
Publication Statistics
PubMed Score 64.02
PubMed score by year
PubTator Score 18.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title