NKX3-2
Homeobox protein Nkx-3.2
Protein Summary
Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity). This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development. [provided by RefSeq, Jul 2008]
- ENST00000382438
- ENSP00000371875
- ENSG00000109705
- BAPX1
- NKX3B
- SMMD
- BAPX1
- NKX3B
- NKX3.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.79 | ||
molecular function | 0.76 | ||
small molecule perturbation | 0.63 | ||
PubMedID | 0.59 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.02 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 186 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.02 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 186 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (53)
Nearest Tclin Targets
Pathways (12)
Reactome (5)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | Regulation of RUNX2 expression and activity | ||||
Reactome | Transcriptional regulation by RUNX2 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
Regulation of RUNX2 expression and activity | ||||
Transcriptional regulation by RUNX2 | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (1)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hip geometry | 1 | 1 | 1 | 37.6 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hip geometry | 1 | 37.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:108015 | 12020 | ||||||
Dog | NK3 homeobox 2 | VGNC:43836 | 488822 | |||||
Cow | NK3 homeobox 2 | VGNC:32106 | 616907 | |||||
Opossum | NK3 homeobox 2 | 100016352 | ||||||
Xenopus | NK3 homeobox 2 | XB-GENE-876834 | 100497965 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Dog | NK3 homeobox 2 | |||||
Cow | NK3 homeobox 2 | |||||
Opossum | NK3 homeobox 2 | |||||
Xenopus | NK3 homeobox 2 | |||||
Publication Statistics
PubMed Score 64.02
PubMed score by year
PubTator Score 18.04
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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