ABCA4
Retinal-specific ATP-binding cassette transporter
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
gene perturbation | 0.98 | ||
trait | 0.86 | ||
cellular component | 0.85 | ||
protein domain | 0.85 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ABC-family proteins mediated transport | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with visual transduction | ||||
Reactome | Diseases of signal transduction | ||||
Reactome | G alpha (i) signalling events | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ABC-family proteins mediated transport | ||||
Disease | ||||
Diseases associated with visual transduction | ||||
Diseases of signal transduction | ||||
G alpha (i) signalling events | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
3 | 3 | 0 | 1.5 | 84 | |||||
Cleft palate | 2 | 2 | 0 | 1.5 | 80 | ||||
Oral cleft | 1 | 2 | 0 | 1.4 | 74.7 | ||||
serum non-albumin protein measurement | 1 | 1 | 1 | 64.4 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 7.4 | 58.4 | ||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.5 | 84 | |||||
Cleft palate | 0 | 1.5 | 80 | ||||
Oral cleft | 0 | 1.4 | 74.7 | ||||
serum non-albumin protein measurement | 1 | 64.4 | |||||
aspartate aminotransferase measurement | 0 | 7.4 | 58.4 | ||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily A member 4 | VGNC:21 | 745972 | |||||
Macaque | ATP binding cassette subfamily A member 4 | 714054 | ||||||
Mouse | MGI:109424 | 11304 | ||||||
Rat | RGD:1309445 | 310836 | ||||||
Dog | ATP binding cassette subfamily A member 4 | VGNC:37427 | 444852 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ATP binding cassette subfamily A member 4 | |||||
Macaque | ATP binding cassette subfamily A member 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATP binding cassette subfamily A member 4 | |||||
PMID | Year | Title |
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