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Tchem
PIP4K2B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Protein Summary
Description
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613180
  • ENSP00000480776
  • ENSG00000277292
  • ENST00000619039
  • ENSP00000482548
  • ENSG00000276293

Symbol
  • PIP5K2B
  • PI5P4KB
  • PIP5K2B
  • PIP5KIIB
  • PIP5P4KB
  • PIP5KIIbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.96
small molecule
0.85
microRNA
0.79
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nintedanib
chemical structure image
Active Ligands (1)
1 – 1 of 1
CHEMBL603469
chemical structure image
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
1
2
72.2
body height
2
1
2
72.2
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
72.2
body height
2
72.2
Protein Data Bank (14)
1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (88)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Intracellular signaling by second messengers
Metabolism
Metabolism of lipids
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
CAFA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (125)
1 – 10 of 125
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01130885
p_int: 1
Score: 0.962
Data Source: BioPlex,Reactome,STRINGDB
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.999996966
p_ni: 0.000003034
Data Source: BioPlex
ATG4C
Tbio
Family: Enzyme
Novelty: 0.04175533
p_int: 0.999991758
p_ni: 0.000008242
p_wrong: 1e-9
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.999957725
p_ni: 0.000042275
Score: 0.171
Data Source: BioPlex,STRINGDB
LZTS2
Tbio
Novelty: 0.09515452
p_int: 0.999682539
p_ni: 0.000317458
p_wrong: 3e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
EAF1
Tbio
Novelty: 0.81120425
p_int: 0.999505016
p_ni: 0.000494984
Data Source: BioPlex
ZRANB2
Tbio
Novelty: 0.06105086
p_int: 0.999362946
p_ni: 0.000637054
Score: 0.696
Data Source: BioPlex,STRINGDB
ARHGAP22
Tbio
Family: Enzyme
Novelty: 0.13037853
p_int: 0.99861059
p_ni: 0.00138941
Score: 0.157
Data Source: BioPlex,STRINGDB
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.996929196
p_ni: 0.003070804
Data Source: BioPlex
GPBP1L1
Tdark
Novelty: 0.69320833
p_int: 0.996788509
p_ni: 0.003211491
Data Source: BioPlex
Publication Statistics
PubMed Score  11.68

PubMed score by year
PubTator Score  16.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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