Pharos : Target Details

Tchem

Protein Classes

Protein Summary

Description

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

PIP4K2B

Ensembl ID

ENST00000613180
ENSP00000480776
ENSG00000277292
ENST00000619039
ENSP00000482548
ENSG00000276293

Symbol

PIP5K2B
PI5P4KB
PIP5K2B
PIP5KIIB
PIP5P4KB
PIP5KIIbeta

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99

molecular function	0.96

small molecule	0.85

microRNA	0.79

virus perturbation	0.76

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68 (req: < 5)

View Publications

Gene RIFs: 6 (req: <= 3)

View Gene RIFs

Antibodies: 169 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68 (req: >= 5)

Gene RIFs: 6 (req: > 3)

Antibodies: 169 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Explore Active Ligands

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Explore Approved Drugs

Approved Drugs (1)

1 – 1 of 1

nintedanib

Active Ligands (1)

1 – 1 of 1

CHEMBL603469

GWAS Traits (2)

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1 – 2 of 2

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Evidence (Mean Rank Score)
body height	EFO_0004339	ENSG00000276293	2	1	2	72.2

body height	EFO_0004339	ENSG00000277292	2	1	2	72.2

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Evidence (Mean Rank Score)
body height	EFO_0004339	2	72.2

body height	EFO_0004339	2	72.2

Beta Count

Odds Ratio

Protein Data Bank (14)

1 – 5 of 14

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (88)

Reactome (18)

KEGG (4)

PathwayCommons (5)

WikiPathways (61)

Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Reactome	Intracellular signaling by second messengers	305 targets	R-HSA-9006925

Reactome	Metabolism	2112 targets	R-HSA-1430728

Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160

Generic Transcription Pathway	1195 targets	R-HSA-212436

Intracellular signaling by second messengers	305 targets	R-HSA-9006925

Metabolism	2112 targets	R-HSA-1430728

Metabolism of lipids	740 targets	R-HSA-556833

Gene Ontology Terms (16)

Functions (5)

Components (5)

Processes (6)

Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
1-phosphatidylinositol-5-phosphate 4-kinase activity	Inferred from Experiment (EXP)	Reactome

1-phosphatidylinositol-4-phosphate 5-kinase activity	Inferred from Direct Assay (IDA)	MGI

protein homodimerization activity	Inferred from Direct Assay (IDA)	CAFA

1-phosphatidylinositol-3-phosphate 4-kinase activity	Traceable Author Statement (TAS)	Reactome

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (125)

1 – 10 of 125

See Interactions on String-DB

PIP4K2A

Tbio

Family: Kinase

Novelty: 0.01130885

p_int: 1

Score: 0.962

Data Source: BioPlex,Reactome,STRINGDB

HDGFL2

Tbio

Family: Epigenetic

Novelty: 0.11846257

p_int: 0.999996966

p_ni: 0.000003034

Data Source: BioPlex

ATG4C

Tbio

Family: Enzyme

Novelty: 0.04175533

p_int: 0.999991758

p_ni: 0.000008242

p_wrong: 1e-9

Data Source: BioPlex

HIF1AN

Tbio

Novelty: 0.00861018

p_int: 0.999957725

p_ni: 0.000042275

Score: 0.171

Data Source: BioPlex,STRINGDB

LZTS2

Tbio

Novelty: 0.09515452

p_int: 0.999682539

p_ni: 0.000317458

p_wrong: 3e-9

Score: 0.15

Data Source: BioPlex,STRINGDB

EAF1

Tbio

Novelty: 0.81120425

p_int: 0.999505016

p_ni: 0.000494984

Data Source: BioPlex

ZRANB2

Tbio

Novelty: 0.06105086

p_int: 0.999362946

p_ni: 0.000637054

Score: 0.696

Data Source: BioPlex,STRINGDB

ARHGAP22

Tbio

Family: Enzyme

Novelty: 0.13037853

p_int: 0.99861059

p_ni: 0.00138941

Score: 0.157

Data Source: BioPlex,STRINGDB

AHCYL2

Tbio

Family: Enzyme

Novelty: 0.08695339

p_int: 0.996929196

p_ni: 0.003070804

Data Source: BioPlex

GPBP1L1

Tdark

Novelty: 0.69320833

p_int: 0.996788509

p_ni: 0.003211491

Data Source: BioPlex

Publication Statistics

PubMed Score 11.68

PubMed score by year

PubTator Score 16.97

PubTator score by year

Patents

Amino Acid Sequence

Residue Counts

Protein Sequence

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ProtVista Viewer

Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

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UniProt Keyword


3D-structure

Acetylation

Alternative splicing

ATP-binding

Cell membrane

Complete proteome

Cytoplasm

Endoplasmic reticulum

Kinase

Membrane

GWAS Trait


body height

MGI Phenotype


adipose tissue phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

limbs/digits/tail phenotype

mortality/aging

skeleton phenotype