You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
PIP4K2B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Protein Summary
Description
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000613180
  • ENSP00000480776
  • ENSG00000277292
  • ENST00000619039
  • ENSP00000482548
  • ENSG00000276293

Symbol
  • PIP5K2B
  • PI5P4KB
  • PIP5K2B
  • PIP5KIIB
  • PIP5P4KB
  • PIP5KIIbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
molecular function
0.96
small molecule
0.85
microRNA
0.79
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.68   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (125)
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  1
Score:  0.962
Data Source:  BioPlex,Reactome,STRINGDB
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999996966
p_ni:  0.000003034
Data Source:  BioPlex
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.999991758
p_ni:  0.000008242
p_wrong:  1e-9
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999957725
p_ni:  0.000042275
Score:  0.171
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999682539
p_ni:  0.000317458
p_wrong:  3e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.999505016
p_ni:  0.000494984
Data Source:  BioPlex
ZRANB2
Tbio
Novelty:  0.06105086
p_int:  0.999362946
p_ni:  0.000637054
Score:  0.696
Data Source:  BioPlex,STRINGDB
ARHGAP22
Tbio
Family:  Enzyme
Novelty:  0.13037853
p_int:  0.99861059
p_ni:  0.00138941
Score:  0.157
Data Source:  BioPlex,STRINGDB
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.996929196
p_ni:  0.003070804
Data Source:  BioPlex
GPBP1L1
Tdark
Novelty:  0.69320833
p_int:  0.996788509
p_ni:  0.003211491
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
Pathways (88)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Intracellular signaling by second messengers
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Intracellular signaling by second messengers
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
CAFA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.4
FEV/FEC ratio
1
1
1
78.4
body height
2
1
2
68
body height
2
1
2
68
heel bone mineral density
2
1
2
52.4
Items per page:
1 – 5 of 16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.4
FEV/FEC ratio
1
78.4
body height
2
68
body height
2
68
heel bone mineral density
2
52.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1934234
108083
Rat
RGD:621710
89812
Dog
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
VGNC:44571
491034
Horse
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
VGNC:21463
100055236
Cow
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
VGNC:32907
539211
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Horse
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Cow
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Publication Statistics
PubMed Score 11.68
PubMed score by year
PubTator Score 16.97
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title