PIP4K2B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Protein Summary
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
- ENST00000613180
- ENSP00000480776
- ENSG00000277292
- ENST00000619039
- ENSP00000482548
- ENSG00000276293
- PIP5K2B
- PI5P4KB
- PIP5K2B
- PIP5KIIB
- PIP5P4KB
- PIP5KIIbeta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
molecular function | 0.96 | ||
small molecule | 0.85 | ||
microRNA | 0.79 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.01 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.01 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1