PIP4K2B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Protein Summary
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]
- ENST00000613180
- ENSP00000480776
- ENSG00000277292
- ENST00000619039
- ENSP00000482548
- ENSG00000276293
- PIP5K2B
- PI5P4KB
- PIP5K2B
- PIP5KIIB
- PIP5P4KB
- PIP5KIIbeta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
molecular function | 0.96 | ||
small molecule | 0.85 | ||
microRNA | 0.79 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.68 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.68 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (1)
Protein-Protein Interactions (125)
PIP4K2A
Family: Kinase
Novelty: 0.01130885
p_int: 1
Score: 0.962
Data Source: BioPlex,Reactome,STRINGDB
HDGFL2
Family: Epigenetic
Novelty: 0.11846257
p_int: 0.999996966
p_ni: 0.000003034
Data Source: BioPlex
ATG4C
Family: Enzyme
Novelty: 0.04175533
p_int: 0.999991758
p_ni: 0.000008242
p_wrong: 1e-9
Data Source: BioPlex
HIF1AN
Novelty: 0.00861018
p_int: 0.999957725
p_ni: 0.000042275
Score: 0.171
Data Source: BioPlex,STRINGDB
LZTS2
Novelty: 0.09515452
p_int: 0.999682539
p_ni: 0.000317458
p_wrong: 3e-9
Score: 0.15
Data Source: BioPlex,STRINGDB
ZRANB2
Novelty: 0.06105086
p_int: 0.999362946
p_ni: 0.000637054
Score: 0.696
Data Source: BioPlex,STRINGDB
ARHGAP22
Family: Enzyme
Novelty: 0.13037853
p_int: 0.99861059
p_ni: 0.00138941
Score: 0.157
Data Source: BioPlex,STRINGDB
AHCYL2
Family: Enzyme
Novelty: 0.08695339
p_int: 0.996929196
p_ni: 0.003070804
Data Source: BioPlex
Nearest Tclin Targets (6)
Upstream (4)
Downstream (2)
1 – 4 of 4
Pathways (88)
Reactome (18)
KEGG (4)
PathwayCommons (5)
WikiPathways (61)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Intracellular signaling by second messengers | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Intracellular signaling by second messengers | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (5)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | CAFA | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 78.4 | ||||||
FEV/FEC ratio | 1 | 1 | 1 | 78.4 | ||||||
body height | 2 | 1 | 2 | 68 | ||||||
body height | 2 | 1 | 2 | 68 | ||||||
heel bone mineral density | 2 | 1 | 2 | 52.4 | ||||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 78.4 | |||||
FEV/FEC ratio | 1 | 78.4 | |||||
body height | 2 | 68 | |||||
body height | 2 | 68 | |||||
heel bone mineral density | 2 | 52.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1934234 | 108083 | ||||||
Rat | RGD:621710 | 89812 | ||||||
Dog | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | VGNC:44571 | 491034 | |||||
Horse | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | VGNC:21463 | 100055236 | |||||
Cow | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | VGNC:32907 | 539211 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | |||||
Horse | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | |||||
Cow | phosphatidylinositol-5-phosphate 4-kinase type 2 beta | |||||
Publication Statistics
PubMed Score 11.68
PubMed score by year
PubTator Score 16.97
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (22)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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