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Tchem
DLG4
Disks large homolog 4

Protein Summary
Description
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302955
  • ENSP00000307471
  • ENSG00000132535
  • ENST00000399506
  • ENSP00000382425
  • ENST00000648172
  • ENSP00000497806

Symbol
  • PSD95
  • PSD95
  • SAP90
  • SAP-90
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
protein domain
0.99
biological process
0.96
molecular function
0.94
transcription factor binding site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1686.27   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 770   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1686.27   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 770   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
0
2.1
59.2
low density lipoprotein cholesterol measurement
2
1
2
37
metabolite measurement
1
1
2
36.8
total cholesterol measurement
1
1
1
33.8
hemoglobin measurement
1
1
1
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
0
2.1
59.2
low density lipoprotein cholesterol measurement
2
37
metabolite measurement
2
36.8
total cholesterol measurement
1
33.8
hemoglobin measurement
1
32.6
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
discs large MAGUK scaffold protein 4
714273
Mouse
MGI:1277959
13385
Rat
RGD:68424
29495
Horse
discs large MAGUK scaffold protein 4
VGNC:17210
100061544
Cow
discs large MAGUK scaffold protein 4
VGNC:28086
100137840
Species
Name
OMA
EggNOG
Inparanoid
Macaque
discs large MAGUK scaffold protein 4
Mouse
Rat
Horse
discs large MAGUK scaffold protein 4
Cow
discs large MAGUK scaffold protein 4
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (91)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 38
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Axon guidance
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of NMDA receptors and postsynaptic events
Activation of kainate receptors upon glutamate binding
Assembly and cell surface presentation of NMDA receptors
Axon guidance
Gene Ontology Terms (59)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (473)
1 – 10 of 473
DLGAP1
Tbio
Novelty: 0.01576595
Score: 0.999
Data Source: Reactome,STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00035058
Score: 0.997
Data Source: Reactome,STRINGDB
GRIN2A
Tclin
Family: IC
Novelty: 0.00060035
Score: 0.995
Data Source: Reactome,STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.993
Data Source: STRINGDB
GRIN1
Tclin
Family: IC
Novelty: 0.0011807
Score: 0.993
Data Source: Reactome,STRINGDB
DLGAP4
Tbio
Novelty: 0.06240351
Score: 0.993
Data Source: Reactome,STRINGDB
LRFN1
Tdark
Novelty: 0.21439206
Score: 0.993
Data Source: Reactome,STRINGDB
LRFN2
Tbio
Novelty: 0.07450569
Score: 0.992
Data Source: Reactome,STRINGDB
NLGN1
Tbio
Family: Enzyme
Novelty: 0.0097512
Score: 0.992
Data Source: STRINGDB
GRIA2
Tclin
Family: IC
Novelty: 0.00141257
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  1686.27

PubMed score by year
PubTator Score  663.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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