Protein Classes
Protein Summary
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated s ...more
- ENST00000302955
- ENSP00000307471
- ENSG00000132535
- ENST00000399506
- ENSP00000382425
- ENST00000648172
- ENSP00000497806
- PSD95
- PSD95
- SAP90
- SAP-90
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
protein domain | 0.99 | ||
biological process | 0.96 | ||
molecular function | 0.94 | ||
transcription factor binding site profile | 0.84 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1686.27 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 770 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1686.27 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 770 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (2)
1 – 2 of 2
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 1 | 0 | 2.1 | 59.2 | ||||
low density lipoprotein cholesterol measurement | 2 | 1 | 2 | 37 | |||||
metabolite measurement | 1 | 1 | 2 | 36.8 | |||||
total cholesterol measurement | 1 | 1 | 1 | 33.8 | |||||
hemoglobin measurement | 1 | 1 | 1 | 32.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 0 | 2.1 | 59.2 | ||||
low density lipoprotein cholesterol measurement | 2 | 37 | |||||
metabolite measurement | 2 | 36.8 | |||||
total cholesterol measurement | 1 | 33.8 | |||||
hemoglobin measurement | 1 | 32.6 | |||||
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | discs large MAGUK scaffold protein 4 | 714273 | ||||||
Mouse | MGI:1277959 | 13385 | ||||||
Rat | RGD:68424 | 29495 | ||||||
Horse | discs large MAGUK scaffold protein 4 | VGNC:17210 | 100061544 | |||||
Cow | discs large MAGUK scaffold protein 4 | VGNC:28086 | 100137840 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | discs large MAGUK scaffold protein 4 | |||||
Mouse | ||||||
Rat | ||||||
Horse | discs large MAGUK scaffold protein 4 | |||||
Cow | discs large MAGUK scaffold protein 4 | |||||
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (91)
Reactome (38)
KEGG (4)
PathwayCommons (2)
WikiPathways (47)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 38
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Ca-permeable Kainate Receptor | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Activation of kainate receptors upon glutamate binding | ||||
Reactome | Assembly and cell surface presentation of NMDA receptors | ||||
Reactome | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Ca-permeable Kainate Receptor | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Activation of kainate receptors upon glutamate binding | ||||
Assembly and cell surface presentation of NMDA receptors | ||||
Axon guidance | ||||
Gene Ontology Terms (59)
Functions (13)
Components (22)
Processes (24)
Items per page:
10
1 – 10 of 13
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Protein-Protein Interactions (473)
1 – 10 of 473
DLGAP1
Novelty: 0.01576595
Score: 0.999
Data Source: Reactome,STRINGDB
GRIN2B
Family: IC
Novelty: 0.00035058
Score: 0.997
Data Source: Reactome,STRINGDB
GRIN2A
Family: IC
Novelty: 0.00060035
Score: 0.995
Data Source: Reactome,STRINGDB
GRIA1
Family: IC
Novelty: 0.0005008
Score: 0.993
Data Source: STRINGDB
GRIN1
Family: IC
Novelty: 0.0011807
Score: 0.993
Data Source: Reactome,STRINGDB
DLGAP4
Novelty: 0.06240351
Score: 0.993
Data Source: Reactome,STRINGDB
LRFN1
Novelty: 0.21439206
Score: 0.993
Data Source: Reactome,STRINGDB
LRFN2
Novelty: 0.07450569
Score: 0.992
Data Source: Reactome,STRINGDB
NLGN1
Family: Enzyme
Novelty: 0.0097512
Score: 0.992
Data Source: STRINGDB
GRIA2
Family: IC
Novelty: 0.00141257
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score 1686.27
PubMed score by year
PubTator Score 663.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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