Tchem DLG4 Disks large homolog 4

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Disks Large Homolog 4

DTO Classes

Protein / Receptor / Disks Large Homolog 4

Protein Summary

Description

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78352
• B7Z1S1
• G5E939
• Q92941
• Q9UKK8

Gene Name

• DLG4

Ensembl ID

• ENST00000302955
• ENSP00000307471
• ENSG00000132535
• ENST00000399506
• ENSP00000382425
• ENST00000648172
• ENSP00000497806

Symbol

• PSD95
• PSD95
• SAP90
• SAP-90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	0.99
biological process	0.96
molecular function	0.94
transcription factor binding site profile	0.84

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1739.34   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 770   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1739.34   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 770   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

CHEMBL1688631

DLG4Tchem

Ki : 6.2

CHEMBL1688633

DLG4Tchem

Ki : 6

GWAS Traits (33)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	4	8	7	15.8	99.6
apolipoprotein B measurement	EFO_0004615	2	6	7		97.8
low density lipoprotein cholesterol measurement	EFO_0004611	8	6	13		97.3
total cholesterol measurement	EFO_0004574	5	5	9		96.5
birth weight	EFO_0004344	4	3	4		89.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
alkaline phosphatase measurement	EFO_0004533	7	15.8	99.6
apolipoprotein B measurement	EFO_0004615	7		97.8
low density lipoprotein cholesterol measurement	EFO_0004611	13		97.3
total cholesterol measurement	EFO_0004574	9		96.5
birth weight	EFO_0004344	4		89.4

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Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	discs large MAGUK scaffold protein 4		714273
Mouse	discs large MAGUK scaffold protein 4	MGI:1277959	13385
Rat	discs large MAGUK scaffold protein 4	RGD:68424	29495
Horse	discs large MAGUK scaffold protein 4	VGNC:17210	100061544
Cow	discs large MAGUK scaffold protein 4	VGNC:28086	100137840

Species	Name	OMA	EggNOG	Inparanoid
Macaque	discs large MAGUK scaffold protein 4
Mouse	discs large MAGUK scaffold protein 4
Rat	discs large MAGUK scaffold protein 4
Horse	discs large MAGUK scaffold protein 4
Cow	discs large MAGUK scaffold protein 4

Protein Structure (15 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

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More information can be found at RCSB PDB

AF-P78352-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (91)

Reactome (38)

KEGG (4)

PathwayCommons (2)

WikiPathways (47)

Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Ca-permeable Kainate Receptor	10 targets	R-HSA-451308
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Reactome	Assembly and cell surface presentation of NMDA receptors	24 targets	R-HSA-9609736
Reactome	Axon guidance	533 targets	R-HSA-422475

Name	Explore in Pharos	Explore in Source
Activation of Ca-permeable Kainate Receptor	10 targets	R-HSA-451308
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Assembly and cell surface presentation of NMDA receptors	24 targets	R-HSA-9609736
Axon guidance	533 targets	R-HSA-422475

Gene Ontology Terms (59)

Functions (13)

Components (22)

Processes (24)

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1 – 10 of 13

GO Term	Evidence	Assigned by
kinase binding	Inferred from Direct Assay (IDA)	MGI
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
acetylcholine receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
beta-1 adrenergic receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
D1 dopamine receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
ionotropic glutamate receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
neuroligin family protein binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
P2Y1 nucleotide receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
PDZ domain binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
protein phosphatase binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Protein-Protein Interactions (473)

Explore Interacting Targets

1 – 10 of 473

• See Interactions on String-DB

DLGAP1

Tbio

Novelty:  0.01576595

Score:  0.999

Data Source:  Reactome,STRINGDB

GRIN2B

Tclin

Family:  IC

Novelty:  0.00035058

Score:  0.997

Data Source:  Reactome,STRINGDB

GRIN2A

Tclin

Family:  IC

Novelty:  0.00060035

Score:  0.995

Data Source:  Reactome,STRINGDB

GRIA1

Tclin

Family:  IC

Novelty:  0.0005008

Score:  0.993

Data Source:  STRINGDB

GRIN1

Tclin

Family:  IC

Novelty:  0.0011807

Score:  0.993

Data Source:  Reactome,STRINGDB

DLGAP4

Tbio

Novelty:  0.06240351

Score:  0.993

Data Source:  Reactome,STRINGDB

LRFN1

Tdark

Novelty:  0.21439206

Score:  0.993

Data Source:  Reactome,STRINGDB

LRFN2

Tbio

Novelty:  0.07450569

Score:  0.992

Data Source:  Reactome,STRINGDB

NLGN1

Tbio

Family:  Enzyme

Novelty:  0.0097512

Score:  0.992

Data Source:  STRINGDB

GRIA2

Tclin

Family:  IC

Novelty:  0.00141257

Score:  0.991

Data Source:  STRINGDB

Publication Statistics

PubMed Score  1739.34

PubMed score by year

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PubTator Score  663.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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alkaline phosphatase measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
birth weight
body height at birth
C-reactive protein measurement
diastolic blood pressure
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