Tchem DLG4 Disks large homolog 4

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Disks Large Homolog 4

DTO Classes

Protein / Receptor / Disks Large Homolog 4

Protein Summary

Description

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P78352
• B7Z1S1
• G5E939
• Q92941
• Q9UKK8

Gene Name

• DLG4

Ensembl ID

• ENST00000302955
• ENSP00000307471
• ENSG00000132535
• ENST00000399506
• ENSP00000382425
• ENST00000648172
• ENSP00000497806

Symbol

• PSD95
• PSD95
• SAP90
• SAP-90

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	0.99
biological process	0.96
molecular function	0.94
transcription factor binding site profile	0.84

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1146.29   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 770   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1146.29   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 770   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (2)

Explore Active Ligands

1 – 2 of 2

CHEMBL1688633

DLG4Tchem

Ki: 6

CHEMBL1688631

DLG4Tchem

Ki: 6.2

Protein Data Bank (15)

1 – 5 of 15

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (91)

Reactome (38)

KEGG (4)

PathwayCommons (2)

WikiPathways (47)

Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

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Items per page:

5

1 – 5 of 38

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of Ca-permeable Kainate Receptor	10 targets	R-HSA-451308
Reactome	Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Reactome	Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Reactome	Assembly and cell surface presentation of NMDA receptors	24 targets	R-HSA-9609736
Reactome	Axon guidance	533 targets	R-HSA-422475

Name	Explore in Pharos	Explore in Source
Activation of Ca-permeable Kainate Receptor	10 targets	R-HSA-451308
Activation of NMDA receptors and postsynaptic events	74 targets	R-HSA-442755
Activation of kainate receptors upon glutamate binding	30 targets	R-HSA-451326
Assembly and cell surface presentation of NMDA receptors	24 targets	R-HSA-9609736
Axon guidance	533 targets	R-HSA-422475

Gene Ontology Terms (59)

Functions (13)

Components (22)

Processes (24)

Items per page:

10

1 – 10 of 13

GO Term	Evidence	Assigned by
kinase binding	Inferred from Direct Assay (IDA)	MGI
protein C-terminus binding	Inferred from Physical Interaction (IPI)	UniProtKB
acetylcholine receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
beta-1 adrenergic receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
D1 dopamine receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
ionotropic glutamate receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
neuroligin family protein binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
P2Y1 nucleotide receptor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
PDZ domain binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
protein phosphatase binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Protein-Protein Interactions (473)

Explore Interacting Targets

1 – 10 of 473

• See Interactions on String-DB

DLGAP1

Tbio

Novelty: 0.02426833

Score: 0.999

Data Source: Reactome,STRINGDB

GRIN2B

Tclin

Family: IC

Novelty: 0.00042857

Score: 0.997

Data Source: Reactome,STRINGDB

GRIN2A

Tclin

Family: IC

Novelty: 0.00075253

Score: 0.995

Data Source: Reactome,STRINGDB

GRIA1

Tclin

Family: IC

Novelty: 0.00063312

Score: 0.993

Data Source: STRINGDB

GRIN1

Tclin

Family: IC

Novelty: 0.00132693

Score: 0.993

Data Source: Reactome,STRINGDB

DLGAP4

Tbio

Novelty: 0.08799804

Score: 0.993

Data Source: Reactome,STRINGDB

LRFN1

Tdark

Novelty: 0.39585297

Score: 0.993

Data Source: Reactome,STRINGDB

LRFN2

Tbio

Novelty: 0.13401404

Score: 0.992

Data Source: Reactome,STRINGDB

NLGN1

Tbio

Family: Enzyme

Novelty: 0.01074328

Score: 0.992

Data Source: STRINGDB

GRIA2

Tclin

Family: IC

Novelty: 0.00187801

Score: 0.991

Data Source: STRINGDB

Publication Statistics

PubMed Score  1146.29

PubMed score by year

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PubTator Score  663.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLER

1-70

GNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEA

70-140

GSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGD

140-210

KILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGT

210-280

DYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLS

280-350

GELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGT

350-420

ASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPS

420-490

KRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFG

490-560

SCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDV

560-630

SANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEI

630-700

YHKVKRVIEDLSGPYIWVPARERL

700-724

MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL

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