Protein Summary
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated s ...more
- ENST00000302955
- ENSP00000307471
- ENSG00000132535
- ENST00000399506
- ENSP00000382425
- ENST00000648172
- ENSP00000497806
- PSD95
- PSD95
- SAP90
- SAP-90
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
protein domain | 0.99 | ||
biological process | 0.96 | ||
molecular function | 0.94 | ||
transcription factor binding site profile | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1739.34 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 770 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1739.34 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 770 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (473)
Nearest Tclin Targets (14)
Upstream (7)
Downstream (7)
1 – 5 of 7
Pathways (91)
Reactome (38)
KEGG (4)
PathwayCommons (2)
WikiPathways (47)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of Ca-permeable Kainate Receptor | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Activation of kainate receptors upon glutamate binding | ||||
Reactome | Assembly and cell surface presentation of NMDA receptors | ||||
Reactome | Axon guidance | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of Ca-permeable Kainate Receptor | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Activation of kainate receptors upon glutamate binding | ||||
Assembly and cell surface presentation of NMDA receptors | ||||
Axon guidance | ||||
Viral Interactions (0)
Gene Ontology Terms (59)
Functions (13)
Components (22)
Processes (24)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (33)
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 4 | 8 | 7 | 15.8 | 99.6 | ||||
apolipoprotein B measurement | 2 | 6 | 7 | 97.8 | |||||
low density lipoprotein cholesterol measurement | 8 | 6 | 13 | 97.3 | |||||
total cholesterol measurement | 5 | 5 | 9 | 96.5 | |||||
birth weight | 4 | 3 | 4 | 89.4 | |||||
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 7 | 15.8 | 99.6 | ||||
apolipoprotein B measurement | 7 | 97.8 | |||||
low density lipoprotein cholesterol measurement | 13 | 97.3 | |||||
total cholesterol measurement | 9 | 96.5 | |||||
birth weight | 4 | 89.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | discs large MAGUK scaffold protein 4 | 714273 | ||||||
Mouse | MGI:1277959 | 13385 | ||||||
Rat | RGD:68424 | 29495 | ||||||
Horse | discs large MAGUK scaffold protein 4 | VGNC:17210 | 100061544 | |||||
Cow | discs large MAGUK scaffold protein 4 | VGNC:28086 | 100137840 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | discs large MAGUK scaffold protein 4 | |||||
Mouse | ||||||
Rat | ||||||
Horse | discs large MAGUK scaffold protein 4 | |||||
Cow | discs large MAGUK scaffold protein 4 | |||||
Publication Statistics
PubMed Score 1739.34
PubMed score by year
PubTator Score 663.47
PubTator score by year
Related Publications
Text Mined References (172)
GeneRif Annotations (56)
Items per page:
0 of 0
PMID | Year | Title |
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