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Tchem
ASIC1
Acid-sensing ion channel 1

Protein Summary
Description
Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the cir ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228468
  • ENSP00000228468
  • ENSG00000110881
  • ENST00000447966
  • ENSP00000400228
  • ENST00000552438
  • ENSP00000450247

Symbol
  • ACCN2
  • BNAC2
  • ASIC
  • ACCN2
  • BNaC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
transcription factor binding site profile
0.7
cell type or tissue
0.66
transcription factor
0.65
tissue sample
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.89   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 356   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.89   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 356   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit 1
VGNC:4938
451888
Macaque
acid sensing ion channel subunit 1
713320
Mouse
MGI:1194915
11419
Rat
RGD:71062
79123
Dog
acid sensing ion channel subunit 1
VGNC:38177
477612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid sensing ion channel subunit 1
Macaque
acid sensing ion channel subunit 1
Mouse
Rat
Dog
acid sensing ion channel subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P78348-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Protein-Protein Interactions (51)
1 – 10 of 51
ASIC2
Tchem
Family: IC
Novelty: 0.00255005
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.607
Data Source: BioPlex,STRINGDB
TNFRSF10B
Tbio
Novelty: 0.00054433
p_int: 0.992168991
p_ni: 0.007830424
p_wrong: 5.85e-7
Data Source: BioPlex
SLC27A3
Tbio
Family: Transporter
Novelty: 0.1037612
p_int: 0.98848839
p_ni: 0.01151161
Score: 0.169
Data Source: BioPlex,STRINGDB
UFSP2
Tbio
Family: Enzyme
Novelty: 0.12630722
p_int: 0.969007395
p_ni: 0.030992605
Score: 0.173
Data Source: BioPlex,STRINGDB
C15orf32
Tdark
Novelty: 8.4527027
p_int: 0.961484537
p_ni: 0.03850551
p_wrong: 0.000009953
Data Source: BioPlex
DPEP1
Tclin
Family: Enzyme
Novelty: 0.00384946
p_int: 0.934105631
p_ni: 0.065894369
Data Source: BioPlex
EIF2AK3
Tchem
Family: Kinase
Novelty: 0.00044559
p_int: 0.78123641
p_ni: 0.215573728
p_wrong: 0.003189862
Score: 0.181
Data Source: BioPlex,STRINGDB
HMOX2
Tchem
Family: Enzyme
Novelty: 0.00180703
p_int: 0.772098711
p_ni: 0.227901289
Score: 0.173
Data Source: BioPlex,STRINGDB
UPK2
Tbio
Novelty: 0.01066132
p_int: 0.751859107
p_ni: 0.248140111
p_wrong: 7.82e-7
Data Source: BioPlex
STOM
Tbio
Novelty: 0.00459891
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  142.89

PubMed score by year
PubTator Score  288.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer