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Tbio
GTF2I
General transcription factor II-I

Protein Summary
Description
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in William ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000443166
  • ENSP00000404240
  • ENSG00000263001
  • ENST00000573035
  • ENSP00000460070
  • ENST00000614986
  • ENSP00000484526
  • ENST00000620879
  • ENSP00000477837
  • ENST00000621734
  • ENSP00000482476

Symbol
  • BAP135
  • WBSCR6
  • WBS
  • DIWS
  • SPIN
  • IB291
  • BAP135
  • BTKAP1
  • TFII-I
  • WBSCR6
  • GTFII-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.99
virus perturbation
0.97
kinase
0.94
transcription factor binding site profile
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.2   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.2   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
2.1
97.1
mathematical ability
2
2
2
87.1
C-reactive protein measurement
2
2
2
83.1
heel bone mineral density
2
2
2
74.9
self reported educational attainment
1
1
1
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.1
97.1
mathematical ability
2
87.1
C-reactive protein measurement
2
83.1
heel bone mineral density
2
74.9
self reported educational attainment
1
72.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIi
574269
Mouse
MGI:1202722
14886
Rat
RGD:727961
353256
Dog
general transcription factor IIi
VGNC:54032
479714
Horse
general transcription factor IIi
VGNC:18641
100060007
Species
Name
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIi
Mouse
Rat
Dog
general transcription factor IIi
Horse
general transcription factor IIi
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P78347-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (114)
1 – 10 of 114
GTF2IRD2B
Tbio
Family: TF
Novelty: 0.14868633
p_int: 0.998095285
p_ni: 0.001904716
Score: 0.606
Data Source: BioPlex,STRINGDB
TIGD6
Tdark
Novelty: 4.01176838
p_int: 0.995834434
p_ni: 0.004165566
Score: 0.306
Data Source: BioPlex,STRINGDB
SOST
Tclin
Novelty: 0.0009273
p_int: 0.991539435
p_ni: 0.008460565
Score: 0.195
Data Source: BioPlex,STRINGDB
PGPEP1
Tbio
Family: Enzyme
Novelty: 0.00933029
p_int: 0.977151693
p_ni: 0.022848307
Score: 0.23
Data Source: BioPlex,STRINGDB
NHLH2
Tbio
Family: TF
Novelty: 0.04744703
p_int: 0.951792566
p_ni: 0.048207434
Data Source: BioPlex
ZNF428
Tdark
Novelty: 3.23887218
p_int: 0.82453315
p_ni: 0.175466849
p_wrong: 2e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
MAGEA1
Tbio
Novelty: 0.00506874
p_int: 0.805097638
p_ni: 0.194902362
Data Source: BioPlex
CYP1A1
Tchem
Novelty: 0.0002404
p_int: 0.776719372
p_ni: 0.223280628
Data Source: BioPlex
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
PRKG1
Tchem
Family: Kinase
Novelty: 0.0014943
Score: 0.911
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.20

PubMed score by year
PubTator Score  91.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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