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Tbio
RPP30
Ribonuclease P protein subunit p30

Protein Summary
Description
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371703
  • ENSP00000360768
  • ENSG00000148688
  • ENST00000413330
  • ENSP00000389182

Symbol
  • RNASEP2
  • TSG15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
histone modification site profile
0.88
ligand (protein) perturbation
0.83
disease perturbation
0.74
microRNA
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left atrial function
1
1
1
4.4
intraocular pressure measurement
1
1
1
3.7
electrocardiography
1
1
3
3.4
heart function measurement
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left atrial function
1
4.4
intraocular pressure measurement
1
3.7
electrocardiography
3
3.4
heart function measurement
1
0.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP subunit p30
VGNC:9776
466155
Macaque
ribonuclease P/MRP subunit p30
696537
Mouse
MGI:1859683
54364
Rat
RGD:1595116
685332
Dog
ribonuclease P/MRP subunit p30
VGNC:45723
477763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP subunit p30
Macaque
ribonuclease P/MRP subunit p30
Mouse
Rat
Dog
ribonuclease P/MRP subunit p30
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P78346-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (163)
1 – 10 of 163
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999999762
p_ni:  2.38e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
p_int:  0.999999744
p_ni:  2.56e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.999999422
p_ni:  5.78e-7
Score:  0.836
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999999059
p_ni:  9.41e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.999998403
p_ni:  0.000001597
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
p_int:  0.999996771
p_ni:  0.000003229
Score:  0.998
Data Source:  BioPlex,STRINGDB
NEPRO
Tbio
Novelty:  0.12980261
p_int:  0.999993817
p_ni:  0.000006183
Score:  0.823
Data Source:  BioPlex,STRINGDB
POP7
Tbio
Family:  Enzyme
Novelty:  0.05460002
p_int:  0.999900925
p_ni:  0.000099075
Score:  0.994
Data Source:  BioPlex,STRINGDB
POP1
Tbio
Family:  Enzyme
Novelty:  2.92497626
p_int:  0.999545488
p_ni:  0.000454512
Score:  0.995
Data Source:  BioPlex,STRINGDB
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.974416135
p_ni:  0.025583866
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  71.01

PubMed score by year
PubTator Score  16.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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