Tbio RPP30 Ribonuclease P protein subunit p30

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Uniprot Accession IDs

• P78346
• B2R799
• E9PB02
• RNaseP protein p30

Gene Name

• RPP30

Ensembl ID

• ENST00000371703
• ENSP00000360768
• ENSG00000148688
• ENST00000413330
• ENSP00000389182

Symbol

• RNASEP2
• TSG15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.94
histone modification site profile	0.88
ligand (protein) perturbation	0.83
disease perturbation	0.74
microRNA	0.69

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Endoribonuclease / Ribonuclease P Protein Subunit P30

Protein / Nucleic Acid Binding / Rna Binding Protein / Endoribonuclease / Ribonuclease P Protein Subunit P30

Protein / Hydrolase / Ribonuclease P Protein Subunit P30

DTO Classes

Protein / Enzyme / Nuclease / Endoribonuclease / Ribonuclease P Protein Subunit P30

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.01   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 74   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.01   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (163)

Explore Interacting Targets

1 – 10 of 163

• See Interactions on String-DB

RPP25

Tbio

Family:  Enzyme

Novelty:  0.07178063

p_int:  0.999999762

p_ni:  2.38e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP14

Tbio

Family:  Enzyme

Novelty:  0.10813341

p_int:  0.999999744

p_ni:  2.56e-7

Score:  0.998

Data Source:  BioPlex,STRINGDB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.999999422

p_ni:  5.78e-7

Score:  0.836

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999999059

p_ni:  9.41e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPP40

Tbio

Family:  Enzyme

Novelty:  0.05981624

p_int:  0.999998403

p_ni:  0.000001597

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP38

Tbio

Family:  Enzyme

Novelty:  0.06387902

p_int:  0.999996771

p_ni:  0.000003229

Score:  0.998

Data Source:  BioPlex,STRINGDB

NEPRO

Tbio

Novelty:  0.12980261

p_int:  0.999993817

p_ni:  0.000006183

Score:  0.823

Data Source:  BioPlex,STRINGDB

POP7

Tbio

Family:  Enzyme

Novelty:  0.05460002

p_int:  0.999900925

p_ni:  0.000099075

Score:  0.994

Data Source:  BioPlex,STRINGDB

POP1

Tbio

Family:  Enzyme

Novelty:  2.92497626

p_int:  0.999545488

p_ni:  0.000454512

Score:  0.995

Data Source:  BioPlex,STRINGDB

POP5

Tbio

Family:  Enzyme

Novelty:  0.02459167

p_int:  0.974416135

p_ni:  0.025583866

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (6)

KEGG (2)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
Reactome	tRNA processing	123 targets	R-HSA-72306

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
tRNA processing	123 targets	R-HSA-72306

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (2)

Components (5)

Processes (2)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ribonuclease P activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
left atrial function	EFO_0004294	1	1	1		4.4
intraocular pressure measurement	EFO_0004695	1	1	1		3.7
electrocardiography	EFO_0004327	1	1	3		3.4
heart function measurement	EFO_0004311	1	1	1		0.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
left atrial function	EFO_0004294	1		4.4
intraocular pressure measurement	EFO_0004695	1		3.7
electrocardiography	EFO_0004327	3		3.4
heart function measurement	EFO_0004311	1		0.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Direct protein sequencing
Hydrolase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
tRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
electrocardiography
heart function measurement
intraocular pressure measurement
left atrial function

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP subunit p30	VGNC:9776	466155
Macaque	ribonuclease P/MRP subunit p30		696537
Mouse	ribonuclease P/MRP 30 subunit	MGI:1859683	54364
Rat	ribonuclease P/MRP subunit p30	RGD:1595116	685332
Dog	ribonuclease P/MRP subunit p30	VGNC:45723	477763

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP subunit p30
Macaque	ribonuclease P/MRP subunit p30
Mouse	ribonuclease P/MRP 30 subunit
Rat	ribonuclease P/MRP subunit p30
Dog	ribonuclease P/MRP subunit p30

Publication Statistics

PubMed Score 71.01

PubMed score by year

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PubTator Score 16.51

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title