Tbio RPP38 Ribonuclease P protein subunit p38

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.

Uniprot Accession IDs

• P78345
• B3KPY0
• D3DRT8
• Q53F71
• Q8NHS8
• RNaseP protein p38

Gene Name

• RPP38

Ensembl ID

• ENST00000378197
• ENSP00000367439
• ENSG00000152464
• ENST00000378202
• ENSP00000367444
• ENST00000378203
• ENSP00000367445
• ENST00000616640
• ENSP00000478982

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
virus perturbation	0.72
interacting protein	0.71
tissue sample	0.67
cellular component	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.83   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.83   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (413)

Explore Interacting Targets

1 – 10 of 413

• See Interactions on String-DB

RPP30

Tbio

Family:  Enzyme

Novelty:  0.01375777

p_int:  0.999996771

p_ni:  0.000003229

Score:  0.998

Data Source:  BioPlex,STRINGDB

RPP25L

Tdark

Family:  Enzyme

Novelty:  1.39761189

p_int:  0.999990594

p_ni:  0.000009406

Score:  0.958

Data Source:  BioPlex,STRINGDB

RPP25

Tbio

Family:  Enzyme

Novelty:  0.07178063

p_int:  0.999979439

p_ni:  0.000020561

Score:  0.998

Data Source:  BioPlex,STRINGDB

POP5

Tbio

Family:  Enzyme

Novelty:  0.02459167

p_int:  0.999963178

p_ni:  0.000036821

Score:  0.994

Data Source:  BioPlex,STRINGDB

RPP21

Tbio

Family:  Enzyme

Novelty:  0.05805689

p_int:  0.999935381

p_ni:  0.000064619

Score:  0.997

Data Source:  BioPlex,STRINGDB

POP4

Tbio

Family:  Enzyme

Novelty:  0.01072287

p_int:  0.999778165

p_ni:  0.000221835

Score:  0.999

Data Source:  BioPlex,STRINGDB

C18orf21

Tdark

Novelty:  0.65363998

p_int:  0.998927545

p_ni:  0.001072454

p_wrong:  1e-9

Score:  0.806

Data Source:  BioPlex,STRINGDB

NEPRO

Tbio

Novelty:  0.12980261

p_int:  0.99746468

p_ni:  0.00253532

Score:  0.183

Data Source:  BioPlex,STRINGDB

NPM1

Tbio

Novelty:  0.0005485

p_int:  0.988299448

p_ni:  0.011700549

p_wrong:  3e-9

Score:  0.219

Data Source:  BioPlex,STRINGDB

IFT27

Tbio

Family:  Enzyme

Novelty:  0.05592902

p_int:  0.927625962

p_ni:  0.072373898

p_wrong:  1.4e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (9)

Reactome (6)

KEGG (2)

WikiPathways (1)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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5

1 – 5 of 6

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
Reactome	tRNA processing	123 targets	R-HSA-72306

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773
tRNA processing	123 targets	R-HSA-72306

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (5)

Processes (1)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
ribonuclease P activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hip circumference	EFO_0005093	1	1	1		0.4
chronic kidney disease	EFO_0003884	1	1	0	1.2	0.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hip circumference	EFO_0005093	1		0.4
chronic kidney disease	EFO_0003884	0	1.2	0.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
Direct protein sequencing
Hydrolase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
tRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
chronic kidney disease
hip circumference

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP subunit p38	VGNC:9777	466016
Macaque	ribonuclease P/MRP subunit p38		100429345
Mouse	ribonuclease P/MRP 38 subunit	MGI:2443607	227522
Rat	ribonuclease P/MRP subunit p38	RGD:1307474	291317
Dog	ribonuclease P/MRP subunit p38	VGNC:45724	100683678

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ribonuclease P/MRP subunit p38
Macaque	ribonuclease P/MRP subunit p38
Mouse	ribonuclease P/MRP 38 subunit
Rat	ribonuclease P/MRP subunit p38
Dog	ribonuclease P/MRP subunit p38

Publication Statistics

PubMed Score 14.83

PubMed score by year

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PubTator Score 11.34

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title