You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RPP38
Ribonuclease P protein subunit p38

Protein Summary
Description
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378197
  • ENSP00000367439
  • ENSG00000152464
  • ENST00000378202
  • ENSP00000367444
  • ENST00000378203
  • ENSP00000367445
  • ENST00000616640
  • ENSP00000478982
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.72
interacting protein
0.71
tissue sample
0.67
cellular component
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (413)
RPP30
Tbio
Family:  Enzyme
Novelty:  0.01375777
p_int:  0.999996771
p_ni:  0.000003229
Score:  0.998
Data Source:  BioPlex,STRINGDB
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999990594
p_ni:  0.000009406
Score:  0.958
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999979439
p_ni:  0.000020561
Score:  0.998
Data Source:  BioPlex,STRINGDB
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.999963178
p_ni:  0.000036821
Score:  0.994
Data Source:  BioPlex,STRINGDB
RPP21
Tbio
Family:  Enzyme
Novelty:  0.05805689
p_int:  0.999935381
p_ni:  0.000064619
Score:  0.997
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999778165
p_ni:  0.000221835
Score:  0.999
Data Source:  BioPlex,STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
p_int:  0.998927545
p_ni:  0.001072454
p_wrong:  1e-9
Score:  0.806
Data Source:  BioPlex,STRINGDB
NEPRO
Tbio
Novelty:  0.12980261
p_int:  0.99746468
p_ni:  0.00253532
Score:  0.183
Data Source:  BioPlex,STRINGDB
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.988299448
p_ni:  0.011700549
p_wrong:  3e-9
Score:  0.219
Data Source:  BioPlex,STRINGDB
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.927625962
p_ni:  0.072373898
p_wrong:  1.4e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
1
1
0.4
1
1
0
1.2
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
0.4
0
1.2
0.3
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP subunit p38
VGNC:9777
466016
Macaque
ribonuclease P/MRP subunit p38
100429345
Mouse
MGI:2443607
227522
Rat
RGD:1307474
291317
Dog
ribonuclease P/MRP subunit p38
VGNC:45724
100683678
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonuclease P/MRP subunit p38
Macaque
ribonuclease P/MRP subunit p38
Mouse
Rat
Dog
ribonuclease P/MRP subunit p38
Publication Statistics
PubMed Score 14.83
PubMed score by year
PubTator Score 11.34
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title