Tbio RPP38 Ribonuclease P protein subunit p38

Protein Summary

Description

Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA as a factor involved in the transport of H1 RNA to the putative site of its assembly in the cell, the nucleolus.

Uniprot Accession IDs

• P78345
• B3KPY0
• D3DRT8
• Q53F71
• Q8NHS8
• RNaseP protein p38

Gene Name

• RPP38

Ensembl ID

• ENST00000378197
• ENSP00000367439
• ENSG00000152464
• ENST00000378202
• ENSP00000367444
• ENST00000378203
• ENSP00000367445
• ENST00000616640
• ENSP00000478982

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
virus perturbation	0.72
interacting protein	0.71
tissue sample	0.67
cellular component	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.52   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0