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Tbio
GPC5
Glypican-5

Protein Summary
Description
Cell surface proteoglycan that bears heparan sulfate. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377067
  • ENSP00000366267
  • ENSG00000179399
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
pathway
0.98
virus perturbation
0.83
disease
0.77
phenotype
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.02   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.02   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (101)
1 – 10 of 101
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.971
Data Source:  STRINGDB
SDC1
Tbio
Novelty:  0.00044792
Score:  0.967
Data Source:  STRINGDB
SDC2
Tbio
Novelty:  0.00597758
Score:  0.967
Data Source:  STRINGDB
SHH
Tchem
Novelty:  0.00028347
Score:  0.966
Data Source:  Reactome,STRINGDB
AGRN
Tbio
Novelty:  0.00156441
Score:  0.966
Data Source:  STRINGDB
SDC3
Tbio
Novelty:  0.01095269
Score:  0.965
Data Source:  STRINGDB
NOTUM
Tchem
Family:  Enzyme
Novelty:  0.02044587
Score:  0.962
Data Source:  Reactome,STRINGDB
NDST1
Tbio
Family:  Enzyme
Novelty:  0.00955868
Score:  0.959
Data Source:  STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.957
Data Source:  STRINGDB
EXT1
Tbio
Family:  Enzyme
Novelty:  0.00355951
Score:  0.955
Data Source:  STRINGDB
Pathways (27)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Reactome
Defective B4GALT7 causes EDS, progeroid type
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Defective B4GALT7 causes EDS, progeroid type
Gene Ontology Terms (12)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
4
3
5.7
81.6
mathematical ability
3
4
4
77.1
heel bone mineral density
2
1
2
76.7
body height
4
2
4
73.2
monocyte percentage of leukocytes
1
1
1
67.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
5.7
81.6
mathematical ability
4
77.1
heel bone mineral density
2
76.7
body height
4
73.2
monocyte percentage of leukocytes
1
67.9
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glypican 5
VGNC:5063
452619
Macaque
glypican 5
100428701
Mouse
MGI:1194894
103978
Dog
glypican 5
VGNC:49903
485518
Horse
glypican 5
VGNC:18486
100058273
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glypican 5
Macaque
glypican 5
Mouse
Dog
glypican 5
Horse
glypican 5
Publication Statistics
PubMed Score 82.02
PubMed score by year
PubTator Score 44.82
PubTator score by year